Exam (elaborations)
NUR 641E MIDTERM STUDY GUIDE 2025 ACTUAL EXAM LATEST QUESTIONS AND DETAILED CORRECT ANSWERS
- Course
- Institution
NUR 641E MIDTERM STUDY GUIDE 2025 ACTUAL EXAM LATEST QUESTIONS AND DETAILED CORRECT ANSWERS
[Show more]
Content preview
NUR 641E MIDTERM STUDY GUIDE 2025ACTUAL EXAM LATEST QUESTIONS
AND DETAILED CORRECT ANSWERS
Bioavailability (is affected by) Correct Answer -chemical
instability
-solubility
-first pass metabolism
Cytochrome P450 Correct Answer -enzymes that function
to metabolize potentially toxic compounds, including drugs
and products of endogenous metabolism such as bilirubin,
principally in the liver.
-genetics influence presence of enzymes
-affects metabolism of warfarin, antidepressants,
antiepileptics, and statins.
-the levels of these drugs are higher when taken with
certain drugs that are inhibitors (ex. warfarin with
omeprazole) because there is competition for enzyme
metabolism.
-inducers lead to decreased plasma concentration of drug.
cytochrome p450 inducer Correct Answer An inducer
increases the metabolism of a substrate resulting in a
decreased level or effect of the substrate
cytochrome p450 inhibitor Correct Answer An inhibitor
decreases the metabolism of a substrate resulting in an
increased level or effect of the substrate.
,Clopidogrel Correct Answer prodrug that must be
activated by hepatic CYP2C19 metabolism; individuals
who are poor metabolizers may not form the active
metabolite and have reduced antiplatelet response
half-life (determines) Correct Answer how often a drug is
administered
4-5 Correct Answer steady state is reached in _-_ times
the half-life
Warfarin (MOA) Correct Answer -Vitamin K antagonist
-Factors II, VII, IX, X
-takes several days to take effect
-monitor INR
Vitamin K Correct Answer warfarin antidote
Heparin (MOA) Correct Answer -rapid anticoagulation by
binding with antithrombin III and inhibits factors IXa, Xa,
XIIa, and XIII
-aPTT monitoring (low dose SQ does not require
monitoring)
Apixaban (MOA) Correct Answer direct factor Xa inhibitor
parenteral administration Correct Answer -directly into
systemic circulation
-poor absorption or unstable in GI tract (ex. heparin,
insulin), rapid absorption, unable to take meds PO
, -IV, IM, SQ, ID
IV Correct Answer -into the vein
-can be given through bolus (rapid peak) or infusion (lower
peak, longer duration)
-ex. rocuronium (neuromuscular blocker)
IM Correct Answer -aqua solutions absorbed rapidly
-depot absorbed slowly in a nonaqueous solution such as
polyethene glycol (simple diffusion)
SQ Correct Answer -absorption via simple diffusion
-constant, slow, and sustained effects
-not for drugs that cause tissue irritation d/t pain and
necrosis
ID Correct Answer -diagnostic determination and allergy
sensitivity
inhalation Correct Answer -drug effects as rapid as IV
bolus
-minimizes systemic side effects of respiratory drugs
oral Correct Answer -antidotes may be provided
-most common, convenient, and economical method of
drug administration
-most complicated drug pathway
-low gastric pH inactivates some drugs
-20-60 minutes for effects
-enteric, extended-release
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller TUTORWAC. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $20.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
79373 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now