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UBC MICB 202 VIROLOGY FINAL EXAM STUDY GUIDE SOLUTIONS
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UBC MICB 202 VIROLOGY FINAL EXAM STUDY GUIDE SOLUTIONS Since viruses are not living cells, they are: - ANSWERObligate intercellular parasites Bacteriophages - ANSWERViruses that infect bacteria In the intercellular state, viruses: - ANSWER- don't respire - don't respond to stimuli - don't mov...

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  • October 31, 2024
  • 38
  • 2024/2025
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  • ubc micb 202 virology final exam study guide solut

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FIRST PUBLISH OCTOBER 2024




UBC MICB 202 VIROLOGY FINAL EXAM

STUDY GUIDE SOLUTIONS


Since viruses are not living cells, they are: - ANSWER✔✔Obligate intercellular parasites


Bacteriophages - ANSWER✔✔Viruses that infect bacteria


In the intercellular state, viruses: - ANSWER✔✔- don't respire


- don't respond to stimuli


- don't move


- don't feed


- don't grow


In the intracellular state, viruses: - ANSWER✔✔- replicate


- adapt


Host cell - ANSWER✔✔A cell that supports the virus's replication of a virus


Infection - ANSWER✔✔When the viral genome is introduced and replicated in a cell

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Capsid - ANSWER✔✔Protein shell enclosing either nucleic acid only or a nucleoprotein complex, or core.

Made up of capsomers. Either helical, icosahedral or complex.


Nucleocapsid - ANSWER✔✔Nucleic acid within an icosahedral protein shell (capsid) or within a helical

capsid.


Envelope - ANSWER✔✔Lipid belayer associated with glycoproteins that surround nucleocapsid


Virion - ANSWER✔✔Intact, fully assembled and infective particle


Core - ANSWER✔✔An internal body found in some viruses containing a nucleoprotein complex within a

capsid.


Icosahedral Capsid - ANSWER✔✔Formed by 20 equilateral triangles. Triangles can be made of single

polypeptides or several.


Helical Capsids - ANSWER✔✔Capsid protein has affinity for viral genome and other copies of capsid

protein (attaches to them). Length of capsid is as long as genome itself.


Complex Capsid - ANSWER✔✔Not well understood.


Naked viruses - ANSWER✔✔Viruses without envelopes.


Capsids dissociate when virus enters the cell: - ANSWER✔✔True


The core dissociates when in enters the cell: - ANSWER✔✔False. Remains intact.

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Length of animal virus replication cycle: - ANSWER✔✔8-24 hrs.


Adsorption - ANSWER✔✔When the virus attaches to the outside of the host cell. Doesn't require energy

from the host cell. Results from random collisions.


Anti-Receptor - ANSWER✔✔On the viral particle.


Virus receptor - ANSWER✔✔On the host cell. May be a protein or the carbohydrates expiration of a

glycoprotein. Note: these are there for normal function, NOT to catch viruses on purpose.


Susceptible cells - ANSWER✔✔Cell types that a virus can infect (enter)


Permissive cells - ANSWER✔✔Cell types in which a virus can multiply


Virus attachment: - ANSWER✔✔- adsorption


- specific attachment


Viral entry - ANSWER✔✔Energy dependent. For any given virus, the same method is always used.


Viral genome can be either: - ANSWER✔✔DNA or RNA, but never both.


Functions of viral genome: - ANSWER✔✔- Template for synthesis of viral genomes or progeny


- To synthesize viral mRNA order to make viral proteins


(+) strand: - ANSWER✔✔Used or make mRNA
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, ©EMILLECT 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED

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(-) strand: - ANSWER✔✔Opposite of (+) strand and complementary.


Monocistronic mRNA - ANSWER✔✔Only contains the coding info for one gene (eukaryotic mRNA)


Polyprotein - ANSWER✔✔A large precursor protein which is enzymatically cleaved into smaller proteins.


DNA viruses: - ANSWER✔✔Replicate DNA using DNA Pol. some use hosts pol, others up ply their own

pre-made pol.


RNA viruses (except retroviruses): - ANSWER✔✔Encode RNA-dependent RNA Polymerases (RNAP)

(normally not found in cells).


Retroviruses: - ANSWER✔✔RNA viruses that use reverse transcriptase to make a single cDNA USING RNA

genome as a template.


Viral Assembly: - ANSWER✔✔- Triggered when concentration of viral genomes and proteins exceeds

threshold.


- depends on inherent rotten affinities


- energetically favorable process


Virus release (egress) by which two methods: - ANSWER✔✔- cell lysing


- cell budding




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