NUR 641E Midterm Exam Study Guide| Questions And Well Elaborated Solutions Graded A| Latest updates
2 views 0 purchase
Course
NUR 641E
Institution
NUR 641E
NUR 641E Midterm Exam Study Guide|
Questions And Well Elaborated Solutions Graded
A| Latest updates
Pharmacokinetics - answer -The process by which drugs are absorbed, distributed
within the body, metabolized, and excreted.
-what the body does to the drug
First pass - answer -the fact that ...
NUR 641E Midterm Exam Study Guide|
Questions And Well Elaborated Solutions Graded
A| Latest updates
Pharmacokinetics - answer -The process by which drugs are absorbed, distributed
within the body, metabolized, and excreted.
-what the body does to the drug
First pass - answer -the fact that a medication in the GI tract passes through the
liver before entering other organs
does not - answer -bioequivalence does/does not affect bioavailability
Bioequivalence - answer -relative therapeutic effectiveness of chemically
equivalent drugs.
Cytochrome P450 - answer --enzymes that function to metabolize potentially toxic
compounds, including drugs and products of endogenous metabolism such as
bilirubin, principally in the liver.
-genetics influence presence of enzymes
-affects metabolism of warfarin, antidepressants, antiepileptics, and statins.
-the levels of these drugs are higher when taken with certain drugs that are
inhibitors (ex. warfarin with omeprazole) because there is competition for enzyme
metabolism.
-inducers lead to decreased plasma concentration of drug.
cytochrome p450 inducer - answer -An inducer increases the metabolism of a
substrate resulting in a decreased level or effect of the substrate
, cytochrome p450 inhibitor - answer -An inhibitor decreases the metabolism of a
substrate resulting in an increased level or effect of the substrate.
Clopidogrel - answer -prodrug that must be activated by hepatic CYP2C19
metabolism; individuals who are poor metabolizers may not form the active
metabolite and have reduced antiplatelet response
half-life (determines) - answer -how often a drug is administered
4-5 - answer -steady state is reached in _-_ times the half-life
Warfarin (MOA) - answer --Vitamin K antagonist
-Factors II, VII, IX, X
-takes several days to take effect
-monitor INR
Vitamin K - answer -warfarin antidote
Heparin (MOA) - answer --rapid anticoagulation by binding with antithrombin III
and inhibits factors IXa, Xa, XIIa, and XIII
-aPTT monitoring (low dose SQ does not require monitoring)
Apixaban (MOA) - answer -direct factor Xa inhibitor
parenteral administration - answer --directly into systemic circulation
-poor absorption or unstable in GI tract (ex. heparin, insulin), rapid absorption,
unable to take meds PO
-IV, IM, SQ, ID
IV - answer --into the vein
-can be given through bolus (rapid peak) or infusion (lower peak, longer duration)
-ex. rocuronium (neuromuscular blocker)
IM - answer --aqua solutions absorbed rapidly
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller TheExamMaestro. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.89. You're not tied to anything after your purchase.
