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CMN 574.1 Exam Questions and Answers 100% Solved

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CMN 574.1 Exam Questions and Answers 100% Solved The most SPECIFIC lab for rheumatoid arthritis is? - anti-CCP antibodies Rheumatoid factor maybe misleading b/c it can also be positive in what conditions? - syphilis, Hep C, TB, subacute endocarditis, or elderly Labs in Early RA disease may on...

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  • October 31, 2024
  • 31
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • CMN 574
  • CMN 574
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CMN 574.1 Exam Questions and

Answers 100% Solved


The most SPECIFIC lab for rheumatoid arthritis is? - ✔✔anti-CCP

antibodies

Rheumatoid factor maybe misleading b/c it can also be positive in what

conditions? - ✔✔syphilis, Hep C, TB, subacute endocarditis, or elderly

Labs in Early RA disease may only have what percent sensitivity? -

✔✔50%

Which joints are affected the most in RA? - ✔✔PIP, MCP, wrists, ankle,

knee, MTP

RA can also affect what other systems besides the joints? - ✔✔ocular,

cardiac, pulmonary, small vessels, subcut tissues(nodules)

Osteoarthritis spares which joints? - ✔✔wrist & MCP

Symmetric AM stiffness is associated with what? - ✔✔RA

T or F: OA/DJD shows less signs of articular inflammation - ✔✔True

,©NINJANERD 2024/2025. YEAR PUBLISHED 2024.
A syndrome consisting of RA, neutropenia, & splenomegaly - ✔✔"Felty

syndrome"

FACT: Early Gout will be monoarticular + urate crystals in the synovial fluid

- ✔✔Later, it may involve multiple joints

1st line Tx for RA? - ✔✔DMARDS

DMARD of choice for RA is? - ✔✔Methotrexate

Absolute contraindications for Methotrexate therapy? - ✔✔Any chronic

hepatitis

What should be Rx with Methotrexate to prevent gastric irritation,

stomatitis, cytopenias, and hepatotoxicity? - ✔✔Folate daily 1mg OR

weekly leucovorin calcium (24hrs after meth dose)

Most frequent SE of Methotrexate is? - ✔✔gastric irritation and stomatitis

What should be avoided in those on methotrexate therapy? - ✔✔Alcohol &

Probenecid, and other folate antagonist drugs (i.e. TMP-SMX)

Methotrexate increases the risk of which cancers? - ✔✔B cell lymphomas

Give DMARDS how long to take effect? - ✔✔2-6 weeks

NSAIDS can provide symptomatic relief for RA pain, but what should also

be Rx with them? - ✔✔PPI for stomach protection

,©NINJANERD 2024/2025. YEAR PUBLISHED 2024.
T or F: all NSAIDS are equivalent in terms of efficacy - ✔✔T, however may

work differently for different people. GIve it 2-3 weeks before trying another

NSAID.

Using a COX-2 inhibitor for RA may be better than NSAIDS b/c why? -

✔✔Less likely to have upper GI adverse events (bleeding, ulceration)

Drawback for COX-2 use? - ✔✔Increased concern for cardiovascular

events (MI, stroke) due to impaired platelet effects

Which medicine may be used as a "bridge" to reduce RA disease activity

while waiting for DMARDs to work? - ✔✔Prednisone- no more than 10mg

day

Intra-articular corticosteroids (triamcinolone) may be helpful in specific

joints with RA, and should not be used more than _______times per year. -

✔✔4

LFTs and CBCs should be checked atleast every______weeks while on

Methotrexate. - ✔✔12 weeks- for hepatotoxicity and cytopenias

2nd line agent for RA? - ✔✔Sulfasalazine

Sulfasalazine can cause hemolysis in which genetic d/o? - ✔✔G6PD-

check for this prior to Rx

SE of Sulfasalazine? - ✔✔neutropenia & thrombocytopenia

, ©NINJANERD 2024/2025. YEAR PUBLISHED 2024.
Check CBCs Q______in those on Sulfasalazine therapy - ✔✔2-4weeks

Xfirst 3 months, then Q3months

Your patient with new Dx RA has an Aspirin sensitivity/allergy, you know

they are contraindicated for which drug? - ✔✔Sulfasalazine

Men and women on Methotrexate should have effective birth control! -

✔✔TRUE

Which antimalarial agent is helpful in RA? - ✔✔hydroxychloroquine sulfate-

only use in those with mild disease b/c only some respond, and it may take

3-6 months. Can be used in combo with sulfasalazine or DMARDs.

SE of hydroxychloroquine sulfate (rare at low doses, but important!) -

✔✔Pigmentary retinitis=> blindness. Inform patient for eye exam

Q12months!

FACT: Minocycline has also been shown to be effective in mild RA (1st

year of dz) - ✔✔Due to the anti-inflammatory properties of the tetracyclines.

AE is dizziness.

The Biologic DMARDs include: - ✔✔TNF inhibitors

Abatacept

Rituximab

Tocilizumab

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