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PSIO 303 Exam 3 Study Questions and Answers

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PSIO 303 Exam 3 Study Questions and Answers The earliest defects that arise with Metabolic Syndrome are impaired glucose tolerance (IGT) and hyperinsulinemia - ANSWER-False All individuals who develop Metabolic Syndrome will eventually develop type 2 diabetes - ANSWER- False Adipose tissue st...

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  • October 30, 2024
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PSIO 303 Exam 3 Study Questions and

Answers


The earliest defects that arise with Metabolic Syndrome are impaired glucose tolerance (IGT) and

hyperinsulinemia - ANSWER✔✔-False


All individuals who develop Metabolic Syndrome will eventually develop type 2 diabetes - ANSWER✔✔-

False


Adipose tissue stores lipid, but also has an endocrine function in the release of cytokines and other types

of chemical messengers (hormones, etc). - ANSWER✔✔-True


The microvascular complications (e.g. retinopathy) of the Metabolic Syndrome start developing during

the phase of compensatory hyperinsulinemia. - ANSWER✔✔-False


When it comes to essential hypertension in Metabolic Syndrome, it is suggested that ___ and ___ may

be responsible for the development of this core component by increasing central sympathetic outflow,

causing peripheral vasoconstriction, and more. - ANSWER✔✔-Insulin resistance ; hyperinsulinemia


What type of "body shape" reflects a greater proportion of visceral adiposity, and thus represents a great

risk group for other components of Metabolic Syndrome? - ANSWER✔✔-Apple


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From the list below, identify the false statements about the role of hypothalamus in glucoregulation.


A. Specific neurons in the hypothalamus can detect changes in glucose and insulin.


B. Because they cannot cross the BBB, adipokines cannot act of the hypothalamus to modulate

peripheral glucoregulation.


C. The hypothalamus can act to modulate neural output to the periphery via the sympathetic nervous

system. - ANSWER✔✔-B is false.


From the list below, identify the correct statements about oxidative stress.


A. It is characterized by excess ROS production


B. It is associated with cell damage and impaired cell signaling.


C. It can be cause by long-term elevations in blood glucose. - ANSWER✔✔-All three correct


From the list below identify the correct statements about the liver and glucose homeostasis.


A. It modulates gluconeogenesis and glycogenolysis in response to insulin and glucagon.


B. It breaks down stored glycogen to glucose in a process called gluconeogenesis.


C. It produces glucose de novo from various substrates in a process known as glycogenolysis.


D. It is the first organ to process nutrients fro the intestines via the hepatic-portal circulation.


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E. It stores glucose in the form of glycogen. - ANSWER✔✔-A, D, E are correct


The magnitude of ultimate intracellular response initiated by ligand binding to plasma membrane

receptors is linearly related to the number of receptors bound by the ligand. - ANSWER✔✔-False


Activation of nuclear receptors induces changed in cellular function through the production of 2nd

messengers. - ANSWER✔✔-False


Select the following statements about the G-protein coupled receptors (GPCRs) that are true.


A. Activation of the alpha subunit of the G-protein occurs when GTP is hydrolyzed to GDP


B. The beta and gamma subunits of G-proteins interact with adenylate cyclases in order to produce

cAMP


C. cAMP (produced after Galphas-protein activation) acts as a 2nd messenger within the cell


D. Activation of the PLC (by Gq-protein activation) results in the production of IP3 and DAG, which have

effects on Ca2+ levels and PKC activity, respectively. - ANSWER✔✔-C and D are correct


Where is the GLUT-2 glucose transport isoform highly expressed? - ANSWER✔✔-Liver and intestine


Which one of the following statements is NOT true of skeletal muscle glucose uptake and its underlying

mechanisms.




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A. Nitric oxide can be stimulated to diffuse to the smooth muscle cells and cause relaxation and

vasodilation.


B. Insulin action on the vascular endothelium of capillaries perfusing skeletal muscle includes decreasing

the number of capillary contacts on the skeletal muscle.


C. Nitric oxide promotes the delivery of glucose and causes leakiness in the endothelium of the

capillaries in contact with the muscle.


D. Insulin can act on the endothelial cells in the capillary bed of the skeletal muscle tissue to activate

nitric oxide synthase (eNOS), leading the nitric oxide production. - ANSWER✔✔-B and C are correct


Insulin can act on the endothelial cells in the arterioles supplying blood to the skeletal muscle tissue to

activate nitric oxide synthase (eNOS), leading to nitric oxide production. - ANSWER✔✔-True


Impairments in both delivery of glucose to the skeletal muscle cell and the transport of glucose into the

cell in response to insulin action contribute to insulin resistance - ANSWER✔✔-True


Only IRS-1 will be affected by the up-regulation of PKC theta by free fatty acids (FFAs) - ANSWER✔✔-

False


The positive effect of tyrosine phosphorylation on the insulin receptor, is not a graded modulation, but

an "all or nothing" response. - ANSWER✔✔-False


Low levels of glucose, as seen by the pancreas, will result in which of the follow?


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