Types of enzymes used for modular construction (2) - ✔✔- Ribosomes
(Make proteins)
- Proteasome (Disassemble protein)
Drugs Common & Uncommon Targets - ✔✔Proteins & Nuclease
How do drugs produce an effect - ✔✔Binding to a biological molecule
How do drugs interact with biological molecules - ✔✔3-D way
Non-covalent interactions - ✔✔Shape and pattern of electron density
determine binding
Covalent bond interactions - ✔✔React chemically with biological molecules
How are amino acids similar - ✔✔- Same backbone
- Same stereochemistry
How do amino acids differ - ✔✔Side (R) chains
Peptides - ✔✔Linear chains of amino acids
Peptide bond - ✔✔The bond between 2 amino acids
Formation of peptide bonds - ✔✔1) Loss of the OH-leaving group
2) N2H of another molecule binds
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