M. tuberculosis damage - ✔✔infection may elicit immune response which
controls infection of an immune response that destroys lung tissue
M. tuberculosis diagnosis - ✔✔culture and microscopy culture sputum,
tuberculin skin test, IFN gamma release test
describe primary infection of M. tuberculosis - ✔✔begins when
contaminated droplets reach alveoli of the lung,, binds to macrophage and
is engulfed by alveolar macrophages but hasn't been activated by a CD4 T
cell therefore cannot digest M. tuberculosis, M. tuberculosis establishes
replicative vacuole, replicates inside macrophage for 7-21 days, destroys
macrophage, recruits macrophages T cell, natural killer cell and dendritic
cells to site of infection, dendritic cells process antigen and present antigen
to MHC I and MHC II proteins
what do CD8 cells with a TCR that recognizes M. tuberulosis antigen do? -
✔✔lyse infected macrophages and dendritic cells, release IFn gamma
which activated macrophages
what do CD4 cells with a TCR that recognizes M. tuberulosis antigen do? -
✔✔differentiate into Th2 and Th1 cells, Th1 release IFN gamma which
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