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NSG 532 Exam 4 |Questions with 100% correct answers
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NSG 532 Exam 4 |Questions with 100% correct answers
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NSG 532 Exam 4 |Questions with 100% correctanswers
Define positive selection - ✔️✔️The process in which double positive T Cells are rescued from
apoptosis and their differentiation into mature CD4+ and CD8+ T cells is induced
Describe negative selection - ✔️✔️PRevention of the maturation of hazardous autoreactive T
cells with self-reactive receptors
Where does B Cell differentiation occur? - ✔️✔️The bone marrow
Describe the process of B Cell differentiation in the bone marrow - ✔️✔️HSC differentiate into
LSC
CD3+ LSC differentiate into CD3+ Pro-BC
Antigen specific receptors are constructed and incorporated into Pro-BC to become Pre-BC
Pre-BC contains CD3 and BCR
Pre-BC further differentiated into CD3+ and BCR+ lymphoblast
Self reactive B cells undergo apoptosis
Differentiated and tested B cells are exported to the lymph node
What can occur to B Cells in the Lymph node? - ✔️✔️B Cells can differentiate into plasma cells in
the lymph node
,Describe the function of the lymph nodes - ✔️✔️Receive antigens from the tissues via lymph
The site of interaction between self and non-self
Describe the structure of the lymph node - ✔️✔️Capsule
Sub Capsular sinus
Cortex
Para Cortex
Medulla
What is the function of the sub-capsular sinus of the lymph node? - ✔️✔️The entryway for lymph
What is contained with the primary follicles of the cortex of the lymph node? - ✔️✔️Virgin B-
Lymphocytes, B-Memory cells, and Antigen Presenting Cells
These are present prior to antigen stimulations
What is contained within the secondary follicles of the cortex of the lymph node? -
✔️✔️Germinal center ---active B lymphocytes
Mantle Zone---resting B lymphocytes
,Cap---B-Cells underoging Plasma cell transition
These are activated following antigen stimulation
What is found in the para-cortex of the lymph node? - ✔️✔️Active T-Lymphocytes
What is found in the medulla of the lymph node? - ✔️✔️APCs and PCs
Describe the Spleen - ✔️✔️The storage and graveyard of RBCs
Stores over half of the bodies monocytes
Receives antigens from tissues via circulation
What is in the red pulp of the spleen? - ✔️✔️RBCs
Monocytes which can go to injured tissues to become macrophages or dendritic cells
What is in the white pulp of the spleen? - ✔️✔️The mantle zone
-contains resting T/B memory cells
Germinal center
-contains B cells
Periarteriolar lymphoid sheath
-contains T-Cells
What are specific immune cells? - ✔️✔️B-Lymphocytes
, T-Lymphocytes
What are non-specific immune cells? - ✔️✔️Phagocytes and antigen presenting cells
Natural Killer Cells
Describe Leukocytopoiesis from BM Multipotent HSCs - ✔️✔️Differentiate into myeloid SCs and
lymphoid SCs
Myeloid SCs -->Myeloblasts
Myeloblasts-->Neutrophils, basophils, eosinophils
Basophils to Monocytes
Monocytes to macrophages or dendritic cells
Lymphoid SCs-->lymphoblasts
Lymphoblasts-->Large Granular Lymphocytes (NKCs) and Small Granular Lymphocytes
Small Granular Lymphocytes into B and T Cells
T Cells further differentiate into TH, TS, TC.
B Cells further differentiate into Plasma cells
Describe functions of Non-Specific Immune Cells - ✔️✔️Neutrophils
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