Genetics 133: Exam 1 Article
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The New Frontier of Doping will Modify Athletes' DNA
(April 13th, 2018) - answer - Sweeney did research on "Schwarzenegger
mice" which were up to 30% stronger by activating IGF-1 which appealed
to athletes who called him to ask him help them use this
- Greeks used sesame seeds, 19th century cocaine caffeine, and alcohol
-Now numerous ways to dope
- Anabolic steroids, stimulants, diuretics, narcotic,
analgesics, EPO (boosts oxygen levels)
-Blood doping/CRISPR-Cas9/AICAR both banned by Anti-doping agency
- Biological passport tries to detect the blood doping agents
Should Athletes be Allowed to Enhance their genes? (April 25, 2019) -
answer -Gene doping is banned in sports, others argue it is the way of
the future
-Gene therapy first developed to treat diseases, but athletes want to use
this same concept for gene doping
could make athletes faster, stronger and longer lasting
-2003 World Anti-doping agency banned gene doping because they have
the potential to enhance performance, could present a health risk and
violate the spirit of sport
-But what if it was safer? Is it inevitable? Could it encourage excellence in
performance? Through the lens of transhumanism, where new
technologies should be interwoven with biological evolution
Post-Covid Bioethics (May 5th, 2020) - answer - Covid-19 is making
bioethics more relevant than ever, who should get ventilators, how do we
protect the most vulnerable, how do we balance surveillance with patient
privacy?
, - Bioethics was born in the 1950s and 60s as a reaction to the atrocities of
world war II and extreme violations of human rights in medical research
and focused on patients rights and autonomy
- now it is working more toward public health ethics
- Covid 19 emphasizes our connectedness and the impacts the actions of
each of us impacts others
- three main areas we need to focus on in bioethics now are distributive
justice, the broader context of healthcare and understanding people are
embedded within their social and cultural networks and exploring the
global aspects of the bioethical dilemmas we are currently facing
- post covid bioethics should place emphasis on fairness, transparency,
trust, solidarity, and compassion as leading values
She thought she was Irish - until a dna test opened a 100 year old mystery
- answer - results from direct to consumer genetics tests can have impact
on life
- Alice Plebuch found jewish ancestry, which led to further relatives
testing, and finding out her dad was mixed up at birth, leaving her feeling
void of identity
- 8 million people worldwide have done direct-to-consumer genetic testing
often used to learn about ancestry, can find unexpected results, in 2014,
7000 users discovered unexpected paternity or previously unknown
siblings
- DNA surprises often imply extramarital affairs, out of wedlock births, and
decades old secrets
23andMe Has a New Genetic Cancer Test. But the Results Don't Tell You
the Whole Story - answer -The FDA approved a 23andMe to test for a
genetic variant for developing colon cancer
New test looks for two gene variants associated with MUTYH-associated
polyposis, an inherited colorectal cancer syndrome, if two copies increases
the risk to 43-100%
-Not the only variant associated with colorectal cancer, only about 5% of
cases are hereditary, and most of those are tied to Lynch syndrome, which
23andMe does not look for
-MUTYH is present in 1-2% of the population, and not all people with get
colorectal cancer, and is also associated with other cancers
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