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NSG 532 IMMUNOLOGY I STUDY TEST
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NSG 532 IMMUNOLOGY I STUDY TEST....
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NSG 532 IMMUNOLOGY I STUDY TESTfacultative intracellular microbes
capable of living and reproducing either inside or outside host cells
epitope
antigenic determinant on non-self; can be antigen or immunogen
antigen
weak or no IR
weak or no memory
reacts with IR products
immunogen
stronger IR
stronger memory
reacts with IR products
common cold virus
weak antigen, changes structure every year; sometimes no immune
response
immunogen criteria (weak/strong)
1. degree of foreignness - more different, better immunogen
2. size and molecular weight (larger = more immune response)
3. chemical nature/complex (proteins are the best immunogen [3D])
,4. ability to degrade to epitopes to create more immune response
5. dose
6. route
hapten
non-immunigenic epitope by itself
hapten example
poison ivy
carrier protein example
skin proteins
conjugated hapten
hapten + carrier protein = immunogenic
primary immune organs
thymus
bone marrow
- site of differentiation, proliferation, & maturation of stem cells into
immune cells
secondary immune organs
lymph nodes
Peyer's patches
tonsils
appendix
- site of interaction between self and non-self
, - site of initiation
- immune responses
HSC differentiate to
lymphoblastic stem cells
lymphoblastic stem cells
differentiate to:
1. T cells in thymus
2. B cells in bone marrow
lymphoblastic stem cells location
bone marrow
stromal epithelial cells
trigger differentiation and maturation of thymocytes (hematopoietic
origin)
thymosine hormone, GF, cytokines
triggers maturation and differentiation in thymus cortex
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