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WGU D027 Advanced Patho Pharmacological Foundations Questions and Answers 2025
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WGU D027 Advanced Patho Pharmacological Foundations Questions and Answers 2025
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1WGU D027 Advanced Patho Pharmacological
Foundations Questions and Answers 2025
What does cholinesterase inhibitors do? - ASNWER-- Prevent the breakdown of
acetylcholine, a chemical messenger that is important for learning and memory
- Supports communication among nerve cells by keeping the acetylcholine high
What are some commonly prescribed cholinesterase inhibitors? - ASNWER--
Donepezil (aricept)
- Galantamine (razadyne)
- Rivastigmine (exeleon)
Which cholinesterase inhibitor can be used for all stages of Alzheimer's? -
ASNWER-- Donepezil (aricept)
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Which cholinesterase inhibitor can be used for mild-to-moderate stages of
Alzheimer's? - ASNWER-- Galantamine (razadyne)
- Rivastigmine (exeleon)
Which cholinesterase inhibitor can be used for mild-to-moderate Alzheimer's and
Parkinson's? - ASNWER-- Rivastigmine (exeleon)
What medication combination is used to treat moderate-to-severe Alzheimer's? -
ASNWER-- Memantine (namenda) and donepezil (aricept)
What are some physical changes from Alzheimer's dementia? - ASNWER-- Brain
shrinks dramatically; nerve cell death and tissue loss
- Cardinal signs: plaques (abnormal clusters of protein fragments) and tangles
(twisted strands of another protein)
How is Alzheimer's treated? - ASNWER-- There is no cure, but there are
pharmacological and non-pharmacological treatments
- Cholinesterase inhibitors
- Memantine (namenda)
What are cholinesterase inhibitors prescribed for? - ASNWER-- To treat symptoms
related to memory, thinking, language, judgment, and other processes
- Helps delay or slow the worsening of symptoms
What is memantine (namenda) used for? - ASNWER-- Prescribed to improve
memory, attention, reason, language, and the ability to perform simple tasks
- Can be used alone or with other Alzheimer's disease treatments
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How does memantine (namenda) work? - ASNWER-- Regulates the activity of
glutamate, a chemical involved in information processing, storage, and retrieval
- Improves mental functioning and ability to perform daily activities for some
people
What is the difference in MOA between cholinesterase inhibitors and memantine
(namenda)? - ASNWER-- Cholinesterase inhibitors prevent the breakdown of
acetylcholine, whereas memantine (namenda) regulates the activity of glutamate
What is ataxia? - ASNWER-- Also known as cerebellum attacks
- Degenerative disease of the nervous system
- Many symptoms mimic those of being drunk (i.e. slurred speech, stumbling,
falling, and incoordination)
What causes the symptoms of ataxia? - ASNWER-- The damage caused to the
cerebellum, the part of the brain that is responsible for coordinating movements
- Can also be caused by damage to part of the spinal cord and nerves
What is the treatment for ataxia? - ASNWER-- No treatment
- In some cases, treating the underlying causes (i.e. stopping medications that
cause ataxia)
- In other cases, it is a result from chicken pox or other viral infections (likely to
resolve on its own)
- Genetic causes/predisposed disposition is usually chronic
What causes ataxia in the pediatric population? - ASNWER-- Genetic
predisposition
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- Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS)
- Prader-Willie Syndrome
What is Fragile X syndrome (FXS)? - ASNWER-- A genetic condition inherited from
parents which results in various developmental problems
- Rare, but may be dangerous or life-threatening
- Present at birth and is a lifelong condition
- Rarely requires lab testing or imaging
- Often linked to autism (1/3 do have autism)
- X-linked disorder
Since Fragile X Syndrome (FXS) is an X-linked disorder, does a specific gender have
a greater risk? - ASNWER-- Often, females are carriers and males are affected
- However, both males and females can be carriers, and both can be affected by
the condition
- Usually milder in females
How did Fragile X Syndrome (FXS) get its name? - ASNWER-- The gene Fragile X
(the FMR1 gene) is on the X syndrome
- Mutation of the FMR1 gene
What is the difference between Fragile X-Associated Tremor/Ataxia Syndrome
(FXTAS) and Fragile X Syndrome (FXS)? - ASNWER-- Both caused by mutations on
the FMR1 gene, but they are caused by different changes in this gene
- FXS is caused by a full mutation
- FXTAS is a premutation
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