NR 507: Advanced Pathophysiology Midterm
Questions And Answers Latest Update
Asthma ANS✔✔ Chronic disease due to bronchoconstriction and an
excessive inflammatory response in the bronchioles
What are 5 s/s of asthma ANS✔✔ coughing
wheezing
shortness of breath
rapid breathing
chest tightness
Pathophysiology of asthma (5) ANS✔✔ -airway inflammation, bronchial
hyper-reactivity and smooth muscle spasm
-excess mucus production and accumulation
-hypertrophy of bronchial smooth muscle
-airflow obstruction
-decreased alveolar ventilation
Bronchioles ANS✔✔ smaller passageways that originate from the bronchi
that become the alveoli
3 layers of the bronchioles ANS✔✔ innermost layer
middle layer - lamina propria
, Solution 2024/2025
Pepper
outermost layer
lamina propria ANS✔✔ the middle layer of the bronchioles
structure of the lamina propria ANS✔✔ embedded with connective tissue
cells and immune cells
purpose of the lamina propria ANS✔✔ white blood cells are present to help
protect the airways
How does the lamina propria effect the lungs in regards to asthma ANS✔✔
the WBCs protective feature goes into overdrive causing an inflammatory
response that damages host tissue
What does the innermost layer of the bronchioles contain ANS✔✔ columnar
epithelial ells and mucus producing goblet cells
What does the outermost layer of the bronchioles contain ANS✔✔ smooth
muscle cells
what does the outermost layer of the bronchioles do ANS✔✔ control the
airways ability to constrict and dilate
alveolar hyperinflation ANS✔✔ When air is unable to move out of the
alveolar like it should due to bronchial walls collapsing around possible
mucus plug thus trapping air inside
, Solution 2024/2025
Pepper
how does hyperinflation occur? ANS✔✔ the ongoing inflammatory process of
asthma produces mucus and pus plug that the bronchial walls collapse
around
Effect of hyperinflation of the alveolar ANS✔✔ -expanded thorax and
hypercapnia (retention of CO2)
- respiratory acidosis
What are two anticholinergic drugs used for asthma ANS✔✔ tiotropium and
ipratropium
What do anticholinergics do in the lungs? ANS✔✔ These drugs block the
effects of the parasympathetic nervous system
- increasing bronchodilation
MOA of anticholinergic drugs for asthma ANS✔✔ the parasympathetic
system is stimulated by the vagal nerve to release acetylcholine which
binds to the cholinergic receptors of the respiratory tract to cause bronchial
constriction = decreased airflow
- blocking the cholinergic receptors prevents acetylcholine binding
preventing the bronchial constriction
bronchitis ANS✔✔ inflammation of the bronchial tubes
3 characteristics of bronchitis ANS✔✔ bronchial inflammation
hypersecretion of mucus
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