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Exam (elaborations)

NR606 Week 4 Questions And Answers Latest Update

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NR606 Week 4 Questions And Answers Latest Update

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  • October 27, 2024
  • 27
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
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Solution 2024/2025
Pepper

NR606 Week 4 Questions And Answers Latest
Update

develop schizophrenia ANS✔✔ -Many genes play a role

• as do epigenetic factors

• Heritability as high as 79%

-gene-environment interaction

-Environmental Triggers:

• Regular Cannabis Use

• Exposure to Early Life Trauma

➣Sexual Abuse

➣Emotional Abuse

➣Emotional Neglect

➣Bullying



schizophrenia Neuroanatomy ANS✔✔ -Mesocortical & ventromedial
prefrontal cortex: negative and affective symptoms



-Dorsolateral: cognitive symptoms



-Orbitofrontal & connections to the amygdala: aggressive, impulsive
symptoms



Brain Circuits Affected in Schizophrenia: ANS✔✔ -Dopamine Pathways

, Solution 2024/2025
Pepper
• explain the (+) & (-) symptoms seen in schizophrenia & psychosis



Dopamine Role in Psychosis ANS✔✔ -leading hypothesis

• psychosis & schizophrenia associated with dysfunction of neurotransmitter
dopamine (DA)

➣Traditionally surplus of dopamine



Glutamate Role in Psychosis ANS✔✔ -primary excitatory neurotransmitter

-implicated in the overactivity of mesolimbic DA pathway in schizophrenia

-Glutamate hypoactivity may result in lost activation of the mesocortical
dopamine pathway leading to negative symptoms of schizophrenia



GABA is the primary _________ neurotransmitter ANS✔✔ inhibitory



Clinical domains of psychosis symptoms: Positive Symptoms ANS✔✔ -
Hallucinations

-Delusions

-Thought disorder

-Hostility

-Excitability



Clinical domains of psychosis symptoms: Motor Symptoms ANS✔✔ -Motor
delay

-Dyscoordination

-EPS, e.g.

, Solution 2024/2025
Pepper
• Parkinsonism

• Dyskinesia



Clinical domains of psychosis symptoms: Affective Symptoms ANS✔✔ -
Depression

-Anxiety

-Suicidality



Clinical domains of psychosis symptoms: Cognition ANS✔✔ -Attention

-Working memory

-Verbal memory

-Visual memory

-Executive functioning

-Processing speed

-Social conditioning



Clinical domains of psychosis symptoms: Negative Symptoms ANS✔✔ -
Affective flattening

-Alogia

-Anhedonia

-Amotivation

-Asociality



Hallucinations: ANS✔✔ -perceptual experiences in the absence of external
stimuli

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