Exam (elaborations)
NSG 531 EXAM 2 QUESTIONS AND ANSWERS
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NSG 531 EXAM 2 QUESTIONS AND ANSWERS...
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Ka is the volume required to obtain 1 mol of free drug when 50% of receptorsare occupied (high related with low free drug and high protein binding).
Kd - The amount of medication required to occupy 50% of receptors.
Log dose ANSWER curve - ANSWER The X-axis represents dosage, while
the Y-axis represents impact. Steeper curves are more risky and difficult to
control.
potency - ANSWER in log-dose curves. highest on the left of the axis; moves to
the right as it becomes less potent.
In log-dose curves, the highest efficacy is represented by the tallest curve,
which travels down the y-axis (down) as efficacy decreases.
Graded ANSWER s: ANSWER uses absolute terms (for example, mmHg). A
steep curve may indicate a minor change in dosage but a significant change in
ANSWER.
Quantal ANSWER s - ANSWER y-axis represents percentage of responders
(those who respond to the therapeutic impact). For example, does a seizure go
away or not?
The therapeutic index is the ratio of a drug's toxic and therapeutic
concentrations. The narrow therapeutic effect is dangerous (difficult to keep out
of toxic range).
agonists - ANSWER activate/stimulate the receptor.
Full agonist - ANSWER has the same maximal action as an intrinsic drug.
partial agonist - ANSWER even if all receptors are full, does not attain the
maximal impact of the intrinsic substance.
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