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NSG 531 PHARM EXAM 1 QUESTIONS AND ANSWERS
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NSG 531 PHARM EXAM 1 QUESTIONS AND ANSWERS...
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Drug absorption occurs at the cell membrane.What is the building block of the cell membrane? - Answer: phospholipid.
The phosphate head is hydrophilic, which means it is drawn to water.
fatty acid tails - ANSWER hydrophobic (water repellent)
Non-ionized - ANSWER Not charged, always lipid soluble, can easily pass the
bilayer.
Ionized - ANSWER charged; always water-soluble; cannot easily traverse the
membrane.
pH is the concentration of H+ ions; lower pH equals higher hydrogen ion
concentration.
pKa - ANSWER indicates the acidity of a given molecule; the lower the pKa,
the stronger the acid (and the ability to transfer a proton).
If the pH is less than pKa, choose ALAN as the answer. Acidic environment
shifts reaction to the left, and acid is nonionized.
If the pH is higher than pKa, the environment is basic. The basic environment
advances the reaction to the right. The acid is ionized, while the base is non-ion
Free drug and Albumin - A higher total drug concentration is related with more
free drug in the plasma and less albumin.
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