NSG 533 Adv Pharm: Module 1: GI: Chp 17 Final Exam And All Complete Answers.
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Course
NSG 533
Institution
NSG 533
Which drug class is most effective in treating erosive lesions:? - Answer PPIs
Name 4 H2RAs: - Answer Cimetidine (Tagamet)
Famotidine (Pepcid)
Ranitidine (Zantac)
Nizatidine (Axid)
What is the action of H2RAs? - Answer Decrease acid secretion by blocking histamine 2-receptors in g...
NSG 533 Adv Pharm: Module 1: GI: Chp
17 Final Exam And All Complete
Answers.
Which drug class is most effective in treating erosive lesions:? - Answer PPIs
Name 4 H2RAs: - Answer Cimetidine (Tagamet)
Famotidine (Pepcid)
Ranitidine (Zantac)
Nizatidine (Axid)
What is the action of H2RAs? - Answer Decrease acid secretion by blocking histamine 2-receptors in
gastric parietal cells
Name 4 benefits of H2RAs - Answer 1. Relieve GERD symptoms
2. Can be administered prophylactically
3. More effective at controlling chronic GERD symptoms than ANTACIDS
4. Intermittent & routine dosing possible based on degree of symptom control needed.
Name 2 drawbacks of H2RAs - Answer 1. Less effective in controlling chronic GERD symptoms than PPIs
2. Renal elimination may require dose adjustment in kidney dysfunction patients
What are the side effects associated with H2RAs? - Answer H/A, nausea (Cimetidine), weak inhibitor,
common drug interactions, gynecomastia, & Vit B-12 deficiency which affects patients' tolerance
Name the benefits of Antacids - Answer 1. Useful for intermittent treatment of GERD symptoms
2. Immediate symptom relief
3. Usually well-tolerated
, What are the drawbacks of Antacids? - Answer 1. Requires frequent dosing
2. Aluminum or Magnesium containing antacids may result in electrolyte imbalances esp. in pts. w/renal
impairment
3. May interfere w/absorption of fluoroquinolones, tetracyclines, iron products, & thyroid hormones
(doses should be several hours apart)
What are the side effects of Antacids? - Answer May cause
Constipation or Diarrhea depending on the formulation used
What is the Pharmacological Therapy Effectiveness of Antacids? - Answer Antacids briefly neutralize
gastric acid but lacks acid-suppressive properties & are inferior to H2RAs
What is the Pharmacological Therapy Effectiveness of H2RAs? - Answer Histamine-2 Receptor
Antagonists decrease acid secretion to a lesser extent than PPIs (& are therefore inferior to PPIs)
What is the Pharmacological Therapy Effectiveness of PPIs? - Answer Proton Pump Inhibitors block the
rate-limiting step in acid secretion from gastric parietal cells & block all pathways for gastric acid
secretion & therefore are better than H2RAs
What is the treatment goal of pharmacological therapy in GERD? - Answer Increase the pH of gastric
content by; 1) Direct gastric acid neutralization 2) Reduce acid production through inhibiting the
stimulation of pathways to decrease GERD symptoms and prevent tissue damage
Which Bariatric Surgery is effective in reducing GERD symptoms in obese patients? - Answer Roux-en-Y
gastric bypass
Which Bariatric Surgery is ineffective in reducing GERD symptoms in obese patients? - Answer Vertical
banded gastroplasty
Which is more beneficial in esophagitis symptom control; Omeprazole or Antireflux surgery? - Answer
In a 7-year follow-up study, Antireflux surgery provided more symptom control in esophagitis patients
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