Why isn't Lyme disease contagious? Answer - You cannot spread Lyme disease
from person to person, you need a tick to spread it.
Exposure to a pathogen does not always result in disease. Why not? Answer - -
No portal of entry
- Physical and chemical barriers
- Protection by normal microbiota
- Host receptor not present
- Innate immunity
- Acquired immunity
three factor that determine if a microbe is beneficial, neutral, or detrimental
Answer - infectious dose, microbe virulence and host immunity
How can a primary infection lead to a secondary infection? Answer - A primary
infection can leave your immune system weakened and more susceptible to
secondary infection.
Secondary infections often comes from bacteria that you already carry
opportunistic pathogens Answer - disease in immunocompromised individuals
- Can also cause disease in healthy individuals if introduced into the wrong
location (e.g. wound)
What are some ways that our normal microbiota protect us from disease?
Answer - Stimulates the adaptive immune response and plays a role in
developing oral tolerance
How does Mycobacterium tuberculosis evade the immune system? Answer - -
Facultative intracellular pathogen
- Produces proteins that direct their uptake by pathogens
- Has an acid-fast cell wall that resists digestion
Bacteria can multiply within human macrophage cells
How do some bacteria evade the complement system? Answer - Antigenic
variation Eg. HIV, Influenza
• Capsule or slime layer
• Facultative intracellular pathogen
• Leukocidins destroy white blood cells
• IgA proteases destroy some antibodies (IgA)
• Elastase inactivates complement proteins
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