The nurse is reviewing factors that influence pharmacokinetics in the neonatal patient. Which factors puts the neonatal patient at risk with regard to drug therapy? (Select all that apply.)
a. Higher gastric pH
b. Increased peristalsis in the GI tract
c. Immature renal function
d. Reduced fi...
The nurse is reviewing factors that influence pharmacokinetics in the neonatal patient. Which factors
puts the neonatal patient at risk with regard to drug therapy? (Select all that apply.)
a. Higher gastric pH
b. Increased peristalsis in the GI tract
c. Immature renal function
d. Reduced first-pass elimination in the liver
e. Decreased protein-binding of medications - correct answer c, d, e
The physiologic differences in the pediatric patient compared with the adult patient affect the amount
of drug needed to produce a therapeutic effect. The nurse is aware that one of the main differences is
that infants have which of these factors?
a. Increased protein in circulation
b. Fat composition lower than 0.001%
c. More muscular body composition
d. Water composition of approximately 75% - correct answer d
While teaching a 76-year-old patient about the adverse effects of his medications, the nurse encourages
him to keep a journal of the adverse effects he experiences. This intervention is important for the older
adult patient because of which altera-tions in pharmacokinetics?
a. Increased renal excretion of protein-bound drugs
b. More alkaline gastric pH, resulting in more adverse effects
c. Decreased blood flow to the liver, resulting in altered metabolism d. Less adipose tissue to store fat-
soluble drugs - correct answer c
When the nurse is reviewing a list of medications taken by an 88-year-old patient, the patient says, "I get
dizzy when I stand up." She also states that she has nearly fainted "a time or two" in the afternoons. Her
systolic blood pressure drops 15 points when she stands up. Which type of medication may be
responsible for these effects?
a. Nonsteroidal antiinflammatory drugs (NSAIDs)
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