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N115 TAKE HOME MIDTERM EXAM STUDY QUESTIONS AND ANSWERS

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N115 TAKE HOME MIDTERM EXAM STUDY QUESTIONS AND ANSWERS Which one of the following is not a major feature of an ideal drug? a. demonstrated effectiveness b. covalent interaction with receptor c. receptor selectivity d. no adverse effects - Ans:-ANS: B Variability of drug response in an indiv...

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  • October 23, 2024
  • 46
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • N115
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FIRST PUBLISH OCTOBER 2024




N115 TAKE HOME MIDTERM EXAM
STUDY QUESTIONS AND ANSWERS

Which one of the following is not a major feature of an ideal drug?




a. demonstrated effectiveness


b. covalent interaction with receptor


c. receptor selectivity


d. no adverse effects - Ans:✔✔-ANS: B


Variability of drug response in an individual patient may be introduced by which of the following:




1. genetic differences in drug metabolism


2. covalent interaction with receptor


3. poor compliance and missed doses


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FIRST PUBLISH OCTOBER 2024




4. inadequate record keeping




a. 1 and 2


b. 1 and 3


c. 1,3,4


d. all of the above - Ans:✔✔-ANS: B


Large multi-site clinical trials, usually with thousands of subjects, are conducted in which phase of drug

evaluation prior to FDA approval?




a. Preclinical drug screening


b. Phase 1


c. Phase 2


d. Phase 3 - Ans:✔✔-ANS: D


Which one of the following is the ultimate factor that determines the intensity of drug response?




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1. cellular location of the receptor [intra vs. extracellular]


2. drug concentration at receptor site


3. proportion of nonionized activity to ionized activity


4. prescribed dose




a. 1 only


b. 2 only


c. 1,2,4


d. all of the above - Ans:✔✔-ANS: B


Which of the following pharmacokinetics term describes how drugs move from the site of administration

to the circulation?




a. Absorption


b. Distribution


c. Metabolism

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FIRST PUBLISH OCTOBER 2024




d. Excretion - Ans:✔✔-ANS: A


Which of the following is true regarding a drug that binds extensively to plasma proteins?




a. will likely have a large volume of distribution [Vd]


b. will be readily eliminated by the kidney


c. is unlikely to affect the bioavailability of other drugs


d. only unbound drug is available for distribution - Ans:✔✔-ANS: D


Acidification of the urine by high doses of Vitamin C [ascorbic acid] may result in:




a. better elimination of meperidine [Demerol], a basic drug, due to ion trapping


b. better elimination of aspirin, an acidic drug, due to ion trapping


c. altered concentration gradient and faster absorption of meperidine [Demerol], a basic drug


d. altered concentration gradient and faster absorption of aspirin, an acidic drug - Ans:✔✔-ANS: A


Which of the following does NOT influence the degree to which a drug moves by passive diffusion?



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