VBSC 211 Exam 2 Questions And Expert Answers 2024/25
4 views 0 purchase
Course
VBSC 211
Institution
VBSC 211
repertoire - Correct Answer total number of antibody specificities available to an individual
affinity maturation - Correct Answer The increase in affinity of the antigen-binding sites of antibodies for the antigen that occurs during the course of an adaptive immune response
affinity - Co...
VBSC 211 Exam 2 Questions And Expert Answers
2024/25
repertoire - Correct Answer total number of antibody specificities available to an
individual
affinity maturation - Correct Answer The increase in affinity of the antigen-binding sites
of antibodies for the antigen that occurs during the course of an adaptive immune
response
affinity - Correct Answer measure of the strength with which one molecule binds to
another at a single binding site
constant region - Correct Answer part of an immunoglobulin or T-cell receptor that is of
identical amino acid sequence in molecules of the same isotype but different antigen-
binding specificities
complementarity-determining region (CDR) - Correct Answer short region of high
diversity in amino acid sequence within the variable region of immunoglobulin and T-cell
receptor chains
combinatorial diversity - Correct Answer results from the random recombination of
separate V, D, and J gene segments of the variable region as well as combinatorial
association of light (k,l) and heavy chains
junctional diversity - Correct Answer -DNA sequence variations introduced by the
improper
joining of gene segments during the process of VJ recombination
-The process of repairing the cleaved chromosomes is sloppy
-New DNA sequences are added to the junction between the segments
light chain - Correct Answer -the smaller of the two types
-consists of one variable and one constant domain, and is disulfide-bonded to a heavy
chain in the immunoglobulin molecule
-k and lamda
-V and J gene segments
linear epitope - Correct Answer antigenic structure in a protein that consists of a linear
sequence of amino acids within the protein's primary structure
heavy chain - Correct Answer -larger of the two types
, -consists of one variable domain and a number of constant domains
-V, D, and J gene segments
coding joint - Correct Answer the joint between the ends of two rearranged
immunoglobulin or T-cell receptor gene segments
Class switch recombination - Correct Answer -the process by which a B cell changes
the class of immunoglobulin it makes while preserving the antigenic specificity of the
immunoglobulin
-involves a somatic recombination process that attaches a different heavy chain
constant region gene to the existing variable region exon
isotype - Correct Answer the class of an immunoglobulin each of which has a distinct
heavy chain constant region encoded by a different constant region gene
IgM (immunoglobulin M) - Correct Answer -the class if IG having mu (μ) heavy chains
-the first immunoglobulin to appear on the surface of B cells and the first antibody
secreted during an immune response
-secreted in pentameric form
IgD (immunoglobulin D) - Correct Answer -the class of IG having delta (δ) heavy
chains
-it appears as surface IG on mature naive B cells but its function is unknown
-transcription of IgD is coordinated with that of IgM
IgG (immunoglobulin G) - Correct Answer -the class of IG having gamma (γ) heavy
chains
-the most abundant class of IG in plasma
IgA (immunoglobulin A) - Correct Answer -the class of IG having alpha (α) heavy
chains
-dimeric IgA antibodies are the main antibodies present in mucosal secretions
-monomeric IgA is present in the blood
IgE (immunoglobulin E) - Correct Answer -the class of IG having epsilon (ε) heavy
chains
-IgE is involved in reactions against internal parasites, particularly helminth worms and
in allergic reactions
discontinuous epitope - Correct Answer -an antigenic structure on a protein that is
formed from several separate regions in the primary sequence of a protein brought
together by protein folding
-antibodies that bind conformational epitopes bind only to native folded proteins
Flow cytometry - Correct Answer technique in which individual cells can be counted or
identified by their cell-surface molecules after fluorescent labeling
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Victoria108. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.49. You're not tied to anything after your purchase.
