Linkage Analysis and DNA sequencing Exam Questions and Answers Graded A+
2 views 0 purchase
Course
Linkage Analysis and DNA sequencing
Institution
Linkage Analysis And DNA Sequencing
Linkage Analysis and DNA sequencing Exam Questions and Answers Graded A+
What is linkage analysis? - Answers a tool for mapping the chromosomal position of unknown genes
What is the basic principal behind linkage analysis? - Answers Genes or DNA markers that are linked, that is physically close t...
Linkage Analysis and DNA sequencing Exam Questions and Answers Graded A+
What is linkage analysis? - Answers a tool for mapping the chromosomal position of unknown genes
What is the basic principal behind linkage analysis? - Answers Genes or DNA markers that are linked,
that is physically close to each other on a chromosome, tend to be inherited together (unless disrupted
by recombination)
Linkage violates... - Answers Mendel's Law of Independent Assortment
Why aren't genes on the same chromosome transmitted together 100% of the time? - Answers
Recombination
As the distance between two loci increases, the likelihood of recombination... - Answers Increases
What is a genetic marker? - Answers DNA sequence variant having a known chromosomal location that
geneticists can use as probes for family or population genetic studies and for the construction of genetic
maps
In linkage analysis what are the two possible outcomes for each marker? - Answers Random assortment
and non-random assortment
Define polymorphism. - Answers A genetic marker in which the frequency of the minor allele is >1%
Why do markers used in linkage analysis have to be highly polymorphic? - Answers If a key member of a
pedigree being analyzed is homozygous for a particular marker, which would occur in many pedigrees
for markers that are not highly polymorphic, that marker is not informative in that family because he or
she will pass it down to all offspring regardless of whether it is linked or not linked to the gene of
interest.
What are the types of markers usually used in linkage analysis? - Answers Microsatellite repeats and
SNPs.
What is the major difference between linkage analysis and GWAS? - Answers Linkage analysis analyzes
SNPs (usually) within a family pedigree to observe linkage with the trait of interest to try to locate the
gene of interest. GWAS is analyzing a high number of patients with a disease/disorder and comparing it
to the non-affected population.
What is happening to the cost of exome and whole genome sequencing? - Answers It is decreasing as
technology becomes faster, more efficient, and more accessible.
Define exome sequencing. - Answers only coding exons (~1.5% of the human genomes) are sequenced.
Relatively simple, will only detect functional mutations in exons
Define whole genome sequencing. - Answers The entire human genome is sequenced. Has potential to
assess every variant. Computational analysis much more complicated
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller TutorJosh. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.89. You're not tied to anything after your purchase.
