IMM250 ACTUAL EXAM QUESTIONS AND ANSWERS ALL CORRECT
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Course
IMM250
Institution
IMM250
IMM250 ACTUAL EXAM QUESTIONS AND ANSWERS ALL CORRECT
How can antibodies defend a host against a virus? - Answer- -Antibodies can neutralize the virus by binding to it before it enters a host cell
- Antibodies can bind to virus protein antigens on the infected cell surface leading to complement-m...
IMM250 ACTUAL EXAM QUESTIONS
AND ANSWERS ALL CORRECT
How can antibodies defend a host against a virus? - Answer- -Antibodies can neutralize
the virus by binding to it before it enters a host cell
- Antibodies can bind to virus protein antigens on the infected cell surface leading to
complement-mediated or NK-mediated lysis of the cell.
In neonatal immunity: - Answer- Protective antibodies are obtained from the mother
during pregnancy and breast feeding.
A monoclonal antibody preparation: - Answer- Contains antibodies that have a single
antigen-binding specificity
If a monoclonal antibody has been 'humanized' that means: - Answer- The mouse
constant regions are replaced with human constant regions so it is less likely to induce
an immune response in the patient.
Human influenza does not: - Answer- Infect epithelial cells in all tissues expressing
sialic acid on cell surface carbohydrates
Human influenza: Positive or negative RNA strand? - Answer- Negative strand RNA
virus
How is the viral genome in human influenza replicated? - Answer- Viral RNA
polymerase
How many different types of human influenza? - Answer- 3, A B and C
Consequences of constant mutation of influenza genome are: - Answer- - The
emergence of strains resistant to anti-flu drugs such as Tamil
- The need to create a new vaccine every year
- Antigenic drift
Why are Ferrets a good model for H5N1? - Answer- Because their silica acid residues
are linked to carbohydrates on the surface of epithelial cells of their upper respiratory
tract in the same way as in humans.
How did H1N1 originate in 2009? - Answer- By antigenic shift, and from gene-
reassortment of 4 different viruses circulating in pigs
, AS03 is an adjuvant that was used in Canada to produce the 2009 H1N1 vaccine. What
was the advantage of using this adjuvant? - Answer- It allowed the production of
vaccine containing a lower amount of virus, increasing the number of doses available in
a short time.
Herd immunity to influenza is achieved: - Answer- When the majority of the community
is vaccinated
A vaccine that induces broadly neutralizing antibodies to influenza : - Answer- Would
avoid the need for antibody reformulation every year
In regards of purpose and/or efficacy of vaccination: - Answer- Vaccines work by
inducing a primary adaptive immune response to a given pathogen prior to exposure to
the infectious agent.
What would be the advantage of using OPV, the oral polio vaccine, rather than IPV, the
inactivated polio vaccine? - Answer- OPV, but not IPV, blocks the enteric infection and
transmission of the virus.
Conjugate vaccines resolve a major drawback of vaccines based on bacterial
carbohydrates, which is: - Answer- Failure to induce a memory response
Human Papilloma Virus (HPV): - Answer- - Is associated with cervical cancer
- Is associated with anal cancer
-The vaccine that protects against HPV is recommended for girls at 11-12 years of age
in USA and Canada
We do not have a good vaccine for: - Answer- Malaria
_______ negatively influences the development of a successful HIV vaccine. - Answer-
The high mutation rate of HIV
True of False: The first Ebola breakout in humans occurred in 2014 in West Africa? -
Answer- False
What are CAR T cells? - Answer- - T cells that express an engineered antigen receptor
that does not need antigen presentation by MHC molecules.
- T cells that express an engineered antigen receptor and are used in cancer
immunotherapy
The % of multiple sclerosis (MS) patients with primary progressive disease is about: -
Answer- 10%
With regard to MS risk factors: - Answer- - Gender affects MS susceptibility; the disease
is three-four times more common in women than men.
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