1. Alpha- and Beta-Adrenergic Agonists and Their Indications
Answer
Dobutamine (generic)
Congestive heart failure
Dopamine (generic)Shock
Ephedrine (generic)
Seasonal rhinitis; hypotensive episodes
Epinephrine (Adrenalin, Adrenaclick)
Shock; glaucoma; prolongs effects of regional anesthetic
Norepinephrine (Levophed)
Treat shock or during cardiac arrest to get sympathetic activity
2. Alpha- and Beta Adrenergic Agonists actions
Answer
The effects of these drug are mediated by the adrenergic receptors in target organs; heart rate
increases, bronchi dilate, vasoconstriction occurs, intraocular pressure decreases, glycogenolysis
occurs throughout the body
3. Alpha- and BetaAdrenergic Agonists contraindications
Answer
Pheochromocytoma
Tachyarrhythmias or ventricular fibrillation
Hypovolemia
Halogenatedhydrocarbon general anesthetics
Caution should
4. Alpha- and BetaAdrenergic Agonists adverse effects
Answer
Arrhythmias, hyper- tension, palpitations, angina and dyspnea
Nausea and vomiting
Headache and sweating, tension and anxiety
5. Alpha- and BetaAdrenergic Agonists drug-drug interactions
, Answer
Tricyclic antidepressants and MAOIs Other drugs causing hypertension Adrenergicantagonists
6. Alpha- and BetaAdrenergic Agonists drugs in this class
Answer
Phenylephrine (Neo-Synephrine, and others)
Midodrine (generic) Clonidine (Catapres)
7. Alpha- and BetaAdrenergic Agonists indications
Answer
Ortho static Hypotension, constriction of topical vessels in nose, dilate pupils
8. Alpha- and BetaAdrenergic Agonists contraindications/cautions
Answer
Known allergy
Severe hypertension or tachycardia
Narrow-angle glaucoma
Pregnancy Caution CVD or vasomotor spasm
Thyrotoxicosis or diabetes
Pregnancy
10. Alpha- and BetaAdrenergic Agonists drug-drug interactions
Answer
MAOIs and TCAs Digoxin, beta-blockers, antipsychotics Adrenergic antagonists
11. Beta-Specific Adrenergic Agonists Actions
Answer
Increase heart rate, conductivity, and contractility, bronchodilation, increase blood flow to
skeletal muscles and splanchnic bed, and relaxation of uterus
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