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OST 575 Exam Understanding LFTs |Questions with 100% Correct Answers
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OST 575 Exam Understanding LFTs |Questionswith 100% Correct Answers
Where is alkaline phosphatase found in the body? - ✔️✔️liver
bone
placenta
intestine
What is Alkaline phosphatase useful for determining? - ✔️✔️if increase in bilirubin levels is of
HEPATIC origin
What can be measured along with alkaline phosphatase to help determine if elevated bilirubin
is of hepatic origin? - ✔️✔️GGTP (gamma-glutamyltransferase)
What are the two main uses of GGTP levels? - ✔️✔️help confirm if increased alk. phosph. is
hepatobiliary
Useful in diagnosing *chronic alcohol abuse*
What are the levels of *GGTP that indicate alcohol abuse* (along with 2:1 AST:ALT ratio)? -
✔️✔️*GGT is TWICE* than normal
Measuring what measures the liver's synthesis of proteins and therefore, truly measures liver
function? - ✔️✔️Albumin
What is albumin a good indicator for? What is it NOT a good indicator for? - ✔️✔️GOOD =
chronic liver disease
BAD = acute liver disease (half life is 20 days)
Prothrombin time/INR measures what clotting factors? - ✔️✔️II
, V
VII
X
Biosynthesis of factors II, VII, IX, and X are dependent on what? - ✔️✔️vitamin K
What vitamins are dependent on Vitamin K for biosynthesis? - ✔️✔️II
VII
IX
X
When is the PT/INR prolonged with liver disease? - ✔️✔️Prolonged in cholestasis or severe
hepatocellular disease
*indicates liver failure*
An increasing level of PT/INR in the face of acute hepatitis may be an indicator of what? -
✔️✔️progressive or fulminant liver failure
Hepatocellualr injury means what? - ✔️✔️primary injury to hepatocytes
Cholestatic injury means what? - ✔️✔️Primary injury to bile ducts
What is elevated in Cholestasis injury? - ✔️✔️Alkaline phosphatase
bilirubin
What is elevated in hepatocellular injury? - ✔️✔️AST
ALT
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