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OST 575 Exam Hepatobiliary Disorders II |Questions with 100% Correct Answers
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OST 575 Exam Hepatobiliary Disorders II |Questions with 100% Correct Answers
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OST 575 Exam Hepatobiliary Disorders II|Questions with 100% Correct Answers
What is the clinical presentation usually of autoimmune cholangiopathies? - ✔️✔️jaundice
fatigue
*pruritis*
What are the serum studies for autoimmune cholangiopathies? - ✔️✔️'cholestatic'
increased alkaline phosphatase and GGT
What is a pathologic characteristic of autoimmune cholangiopathies? - ✔️✔️fibrous obliteration
of at least intrahepatic small ducts
What antibodies are sensitive for primary biliary cirrhosis (PBC)? - ✔️✔️AMA
What antibodies are sensitive for primary sclerosing cholangitis? - ✔️✔️pANCA (possibly same
induced T cell activation as ulcerative colitis)
What is the major diagnostic feature of primary biliary cirrhosis? - ✔️✔️*florid duct lesion*
abundant lymphocytes and plasma cells that surround and destroy bile ducts, particularly in
portal tracts
What is another feature of primary biliary cirrhosis that happens due to the inflammatory
process over time? - ✔️✔️develops a *granuloma*
What are the characteristic features of primary sclerosing cholangitis? - ✔️✔️large duct
inflammation and scarring
, What is the histologic presentation of primary sclerosing cholangitis? - ✔️✔️portal tract bile
ducts NOT spared
*show concentric, onion skin fibrosis* that will eventually obliterate the ducts
What can primary sclerosing cholangitis eventually lead to? - ✔️✔️bile stasis
ascending cholangitis
Portal vein obstruction typically causes what type of problems? - ✔️✔️pre hepatic issues
What are the forms of pre hepatic obstruction? - ✔️✔️*IMPAIRED BLOOD FLOW*
portal vein obstruction
intra or extrahepatic thrombosis
What are the forms of intrahepatic obstruction? - ✔️✔️*IMPARIED INTRAHEPATIC BLOOD
FLOW*
cirrhosis
sinusoid occlusion
What are the forms of post hepatic obstruction? - ✔️✔️*HEPATIC VEIN AND OUTFLOW
OBSTRUCTION*
hepatic vein thrombosis
Sinusoidal obstructive syndrome
What are manifestations of pre hepatic obstruction? - ✔️✔️Esophageal varices
splenomegaly
*intestinal congestion*
What are manifestations of intrahepatic obstruction? - ✔️✔️Ascites
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