Psoriasis - Answer-Chronic, multi-system disease
Lifelong illness, can wax and wane
Decreased QOL ad emotional distress
Decreased life expectancy
Epidemiology of psoriasis - Answer-Affects approx. 2% of the U.S. population (mainly caucasian)
Affects men and women equally
Two peaks of onset...
Psoriasis Exam Questions with
Complete Solutions
Psoriasis - Answer-Chronic, multi-system disease
Lifelong illness, can wax and wane
Decreased QOL ad emotional distress
Decreased life expectancy
Epidemiology of psoriasis - Answer-Affects approx. 2% of the U.S. population (mainly
caucasian)
Affects men and women equally
Two peaks of onset: 20-30, 50-60
Etiology of psoriasis - Answer-Strong genetic component
Waxes and wanes throughout the lifetime
Triggers
What are the triggers of Psoriasis? - Answer-Injury to skin (trauma)
Psychogenic stress
climate (cold temperatures)
infection
smoking
alcohol
obesity
medications
What is the pathophysiology of psoriasis? - Answer-Immune mediated chronic
inflammatory disease of the skin. Activated T cells result in epidermal hyperplasia and
dermal inflammation. Cytokines and growth factors contribute to hyperproliferation of
basal cell keratinocytes. Caused by genetic and envt factors
Name the co-morbidities associated with psoriasis - Answer-Psoriatic Arthritis (PsA)
metabolic syndrome
Crohn's disease
Multiple sclerosis
Psychological illness ( anxiety and depression)
cutaneous T-cell lymphoma
Risks associated with Psoriasis - Answer-Decreased life expectancy
increased rates of mortality
Plaque psoriasis - Answer---Well-demarcated plaques w/ white or silvery scale and
underlying red or gray patches
--Start as small papules which grow and unite to form plaques
--Chronic plaque psoriasis--symmetric and bilateral
--Auspitz sign--bleeding after removal of scale
--Koebner phenomenon--lesions induced by trauma
Guttate psoriasis - Answer-Individual small, fine red lesions/scales
Occurs in <2% of patients
Often preceded by bacterial infection such as strep throat
Inverse/Flexural psoriasis - Answer-Erythematous smooth plaques in the axilla, groin,
inframammary region and other skin folds
May lack scale due to moistness of area
More redness, almost looks like a burn
Pustular psoriasis - Answer-Localized pustules on palms and soles
Erythrodermic psoriasis - Answer---WIdespread large, red inflamed patches covering
most of BSA
--Can be gradual or acute
--Looks like an extreme burn
--Emergency situation, pt needs to be hospitalized
80% of psoriasis patients have mild-moderate disease - Answer-<5% BSA
20% of psoriasis patients have moderate-severe psoriasis - Answer->5% BSA
Past medical history - Answer---Can be triggered by infections
--More severe in patients with HIV
--20% of pts have psoriatic arthritis
--Increased BMI correlates with prevalence and severity of psoriasis
--Koebner Phenomenon
Family Hx of psoriasis - Answer---Strong genetic predisposition
--1/3 of pts have +family Hx
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