Opioid Receptor Antagonist (What do we use in Opioid overdoses?) Correct Answer-Naloxone
What do NSAIDS (Nonsteroidal Anti-inflammatory Drugs) inhibit? Correct Answer-Cyclooxygenase (COX) pathways
What are protective prostaglandins? (COX1) Correct Answer-Stomach mucosa, platelet stickiness
...
N398 - Pharmacology Meds questions with correct
answers
Opioid Receptor Antagonist (What do we use in Opioid overdoses?)
Correct Answer-Naloxone
What do NSAIDS (Nonsteroidal Anti-inflammatory Drugs) inhibit?
Correct Answer-Cyclooxygenase (COX) pathways
What are protective prostaglandins? (COX1) Correct Answer-Stomach
mucosa, platelet stickiness
What are inflammatory prostaglandins? (COX2) Correct Answer-Pain,
fever, inflammation
1st Generation NSAID
Non-selective inhibitor of COX
Antipyretic - DO NOT USE IN PEDS
AE: GI effects; bleeding; renal impairment; salicylate toxicity
DI: other NSAIDs, glucocorticoids, anticoagulants
Admin: know your formulations
Pt. Ed: may cause stomach upset take with food Correct Answer-Aspirin
Which classification of drugs act on Mu, Kappa, and Delta receptors?
Correct Answer-Opioids
, What do Mu receptor agonist cause? Correct Answer-Analgesia,
respiratory depression, euphoria, sedation, decreased GI motility,
PHYSICAL DEPENDENCE
What do Kappa receptor agonist cause? Correct Answer-Analgesia &
sedations, decreased GI motility
What do Delta receptor agonist cause? Correct Answer-novel target for
pain and depression treatments
Tolerance Correct Answer-State in which a larger dose is required to
produce same response as before on smaller dose (can be developed to
sedation and respiratory depression but not to the constipation)
Morphine and Oxycodone Correct Answer-Therapeutic Uses: Relief of
pain
MOA: mimic action of endogenous opioid peptides primarily at mu
receptor
DI: CNS depressants, anticholinergic drugs (urine retention, dry mouth,
decrease GI motility.. against PSNS), hypotensive drugs
AE: respiratory depression, constipation, orthostatic hypotension,
urinary retention, cough suppression, biliary colic, emesis, sedation,
euphoria
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