1. Regarding antipsychotic use, which of the following side effects or side effect profiles is
most likely to be seen?
Answer
Tardive Dyskinesia
Rationale Tardive dyskinesia is a common extrapyramidal side effect seen in pa- tients with
long-term treatment. Lip-smacking is a type of tardive dyskinesia seen in patients taking these
drugs.
2. Which of the following diseases or disorder is most commonly associated with antipsychotic
use? (primary use)
Answer
Schizophrenia
Rationale Antipsychotic drugs are primarily indicated for schizophrenia to treat its positive
symptoms. Antipsychotics are also indicated for psychosis and mania.
3. Which of the following diseases or disorder is most commonly associated with Fluphenazine
antipsychotic use?
Answer
Tourette's Syndrome
Rationale Fluphenazine is used to treat Tourette's syndrome, an inherited disease characterized
by motor and phonic tics
4. What is true regarding antipsychotics?
Answer
Lipid-soluble agents.
Rationale Antipsychotics are highly lipid-soluble and are stored in the body fat.They are very
slowly removed from the body and are considered to have a long half-life.
5. Regarding antipsychotic use, which of the following side effects is most likely seen?
Rationale These drugs display alpha 1 blockade effects, sometimes leading to hypotension.
6. Which of the following is a side effect most likely to be seen associated with dry mouth?
Answer
Anticholinergic
(Ant-tie-cola)
Rationale Antipsychotics drugs also block cholinergic receptors, leading to antimus- carinic
effects. Patients can suffer from anticholinergic effects, such as dry mouth and constipation.
7. Which is true regarding the MOA of antipsychotics?
Answer
Block dopamine recep- tors ("Blocking Doberman Receptors")
Rationale Antipsychotic drugs block dopamine D2 receptors in the mesolimbic and
mesocortical areas of the CNS. This leads to an increase of the intracellular concentration of the
second messenger cyclic adenosine monophosphate (cAMP).
8. Which of the following is a side effect most likely to be seen w/ antipsy- chotics?
Answer
Galactorrhea
("Lactating and Pumping Breast milk")
Rationale Galactorrhea is an endocrine side effect r/t dopamine antagonism. Pa- tients typically
have spontaneous outflow of milk from the breasts due to hyperpro- lactinemia stemming from
dopamine antagonism.
9. Which of the following best reflects the time course for the onset of tardive dyskinesia or
Parkinson's like symptoms associated with the use of high potency antipsychotic drugs?
Answer
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