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IMMUNOHEMATOLOGY TEST 4 AUTOIMMUNE HEMOLYTIC ANEMIA QUESTIONS AND ANSWERS.
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IMMUNOHEMATOLOGY TEST 4 AUTOIMMUNE HEMOLYTIC ANEMIA QUESTIONS AND ANSWERS.
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IMMUNOHEMATOLOGY TEST 4AUTOIMMUNE HEMOLYTIC ANEMIA
QUESTIONS AND ANSWERS
Describe nnimmune nnmechanism nnfor nnautoab nnformation nnmechanism nn- nnAnswer
nnOccurs nnbecause nnthere nnis nna nnfailure nnof nnthe nnmechanism nnthe nnregulates nnthe
nnimmune nnresponse
B nnlymphs nnpro nnabs
T nnlymphs nnmodulate nnab nnproduction--if nnT nnsuppressor's nnfunction nnis nnlost, nnan
nnindividual's nnimmune nnsystem nnwill nnmake nnuncontrolled nnamounts nnof nnautoab
thought nnto nnact nnthrough nna nnfeedback nnmechanism
Classifications nnof nnautoimmune nnhemolytic nnanemias nn- nnAnswer nn1. nnCold
nnhemolytic nnanemia
2. nnwarm nnhemolytic nnanemia
3 nndrug nninduced
Thermal nnrange nnand nn2 nncommon nntypes nnof nncold nnhemolytic nnanemias nn-
nnAnswer nnautoab nnreact nnbest nna nn4 nndeg nnC, nnbut nncan nnat nn25-31, nnand nnrarely
nnat nn37
cold nnagglutinin/hemagglutinin nnDisease nn(CAD) nn- nn16%
Paroxysmal nnCold nnHemoglobinuria nn- nn1-2%
Info nnon nnPCH nn- nnAnswer nna nnbiphasic nnantibody nnwhich nnbinds nnin nnthe nncold nn(4-
20 nndeg nnC), nnthe nncells nnare nnhemolyzed nnin nnwarmer nntemps nn(30-37)
Info nnon nnwarm nnhemolytic nnanemia nn- nnAnswer nnmake nnup nn70% nnof nnall
nnautoimmune nnhemolytic nnanemias
autoabs nnreact nnbest nna nn37 nn(range nnof nn20-37)
Info nnon nndrug nninduced nnhemolyic nnanemias nnand nnits nn4 nntypes nn- nnAnswer nn12%
nnof nnall nnautoimmune nnhemolytic nnanemias
37 nndeg nnC nnoptimum nntemp nnof nnreactivity
1. nnimmune nncomplex
2. nndrug nnabsorption
3. nnmembrane nnmodification
, 4. nnautoab nnformation
General nnlab nnfindings nnin nnBB nnindicative nnof nnhemolytic nnanemia nn- nnAnswer
nnpresence nnof nnautoabs
RBC nndestruction nnis nnimmune nnin nnnature
dec nnHCT
Lab nnfindings nnindicative nnextravascular nnhemolysis nn- nnAnswer nninc nnbili
nn(unconjugated--indirect)
inc nnretic nncount nnand nnpresence nnof nnnucleated nnRBCs
abnormal nnRBC nnmorphology nn(schistocytes, nnmicrospherocytes)
Lab nnfindings nnindicative nnintravascular nnhemolysis nn- nnAnswer nndec nnserum
nnhaptoglobin
increased nnLDH nn(espically nnLDH1)
may nnsee nnhemoflobinemia nnand nnhemoglobinuria
Types nnof nnserological nnstudies nnand nnwhy? nn- nnAnswer nnUsed nnto nnconfirm nnand
nncategorize nnhemolytic nnanemia
1. nnDAT nnevalutaion
Eluate
3. nnPresence nnof nnserum nnautoab
Is nnthere nna nncorrelation nnwith nnDAT nnstrength nnand nnseverity nnof nnhemolytic
nnanemia nn- nnAnswer nnNo, nnthe nnpt nncan nnhave nna nnstrong nnpos nnDAT nnand nnno
nnhemolytic nnanemia
Types nnof nnautoabs nnthat nncan nnbe nnID'd nnby nnthe nnDAT nn- nnAnswer nncold, nnwarm,
nnand nndrug nninduced
Strength nnof nnDAT/Info nnon nncold nnautoabs nn- nnAnswer nnC3 nnonly nnon nncells
strong nnpos nnDAT
Strength nnof nnDAT/Info nnon nnwarm nnautoabs nn- nnAnswer nnIgG nnand nnC', nnor nnIgG
nnonly nn(C' nnonly nnnot nnas nncommon)
weak-strong nnpos nnDAT
*Strength nnof nnDAT/Info nnon nndrug nninduced nnhemolytic nnautoabs nnfor nneach
nnmechanism* nn- nnAnswer nnimmune nncomplex nn- nnC3 nnonly nn(qunidine)
drug nnadsorption nn- nnIgG nnonly nnstrong nnpos nn(penicillin)
membrane nnmodification nn- nnIgG nnand nnC3 nn(cephalosporin)
autoab nnformation nn- nnIgG nnstrong nnpos nn(aldomet, nnmethyldopa)
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