Climacteric phase - answer ✅✅The period of endrocrinologic, somatic,
and transitory psychologic changes that occur around the time of
menopause.
Early menopause - answer ✅✅LMP before age 45
Late menopause - answer ✅✅LMP after age 54
Primary ovarian insufficiency - answer ✅✅Menopause that occurs before
age 40
,Early menopause transition (stage -2) - answer ✅✅Persistent difference
of 7 days or more in the length of consecutive cycles.
Late menopause transition (stage -1) - answer ✅✅60 or more consecutive
days of amenorrhea
Luteal out of phase event (LOOP) - answer ✅✅Explains why some
perimenopausal women have elevated estrogen level sometimes...In the
early menopause transition, elevated FSH levels are adequate to recruit a
second follicle which results in a follicular phase-like rise in estradiol
secretion superimposed on the mid-to-late luteal phase of the ongoing
ovulatory cycle.
Obese women and estradiol levels during menopause - answer
✅✅Obese women are more likely to have anovulatory cycles with high
estradiol levels. They are also more likely to have lower premenopause
yet higher postmenopause estradiol levels compared with women of
normal weight. (why they are at higher risk of endometrial cancer)
Chinese and Japanese women - answer ✅✅These ethnic groups have
lower estradiol levels then white, black and hispanic women.
stage +2 - answer ✅✅late menopause stage: 5-8 years after FMP. Somatic
aging predominates. Increased genitourinary symptoms.
,Stages +1a, +1b, +1c - answer ✅✅early post menopause: 2 years after
FMP. FSH rises, estradiol decreases. VMS predominate.
Elevated FSH, LH - answer ✅✅Endocrine labs after menopause
AMH, inhibin B - answer ✅✅These hormones work during
reproductive years to not deplete follicle pool too quickly.
Phases during menopause transition and PMS symptoms - answer
✅✅Menstrual cycle shortenes, follicular phase compresses, women
spend more time in luteal phase.. meaning more premenstrual symptoms
and more frequent menstrual periods.
How to respond if a patient requests FSH lab? - answer ✅✅many
pitfalls, variable depending on the day of the cycle you draw the lab,
normal or low FSH is not helpful.
The potentially superior marker of menopause, a lab. - answer
✅✅AMH
DHEA (dehydroepiandrosterone) - answer ✅✅Adrenal androgens:
precursor hromones produced by the adrenal gland that are enzymatically
converted to active androgens or estrogens in peripheral tissues.
, Location of estrogen receptors - answer ✅✅Vagina, vulva, urethra,
trigone of the bladder
Effects of estrogen on tissue - answer ✅✅maintain blood flow, the
collagen, and HA within the epithelial surfaces. Supports microbiome and
protects tissue from pathogens.
Vaginal changes with menopause - answer ✅✅Thinning, loss of elasticity,
loss or absence or rugae.
Vagina and urethra in menopause - answer ✅✅vagina narrows, urethra
moves closer to the introitus.
Stress urinary incontinence - answer ✅✅Vaginal estrogen and urinary
incontinence: what type does it help with?
Treatment for FPHL - answer ✅✅Minoxidil, spironolactone, finasteride,
estrogen therapy
Late reporoductive years -3b and -3a. What happens with menstrual
cycles, FSH, AMH, AFC, inhibin? - answer ✅✅-3b: menstrual cycles
normal, FSH normal, AMH low, AFC low, inhibin low.
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