Exam (elaborations)
SPMM Pharmacology – Questions & Verified Solutions
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SPMM Pharmacology – Questions & Verified Solutions
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SPMM Pharmacology – Questions & Verified SolutionsButyrophenone drug class Right Ans - Haloperidol, droperidol
Acamprosate MOA Right Ans - Taurine analogue
NMDA antagonist
GABA agonist
Reduced alcohol craving, relapse, anxiety, insomnia and arousal.
Secondary amines Right Ans - Nortriptyline, Desipramine
Secondary amines properties Right Ans - More potent mg to mg than
tertiary amines
Less sedating
Cyproterone MOA and indication Right Ans - Testosterone antagonist
Treatment of hypersexuality and paraphilias
Reversible MAOI Right Ans - Moclobemide - 'cheese reaction' less likely
Lofexidine MOA and indication Right Ans - Alpha-2 agonist
Relieve symptoms of opioid withdrawal
SSRI most highly selective for serotonin Right Ans - Citalopram and
escitalopram
Minimal effect on NA or DA reuptake
Fluoxetine effects on other drug metabolism Right Ans - CYP2D6 and
CYP3A4 inhibitor - increases levels of beta-blocker, carbamezapine, phenytoin
and haloperidol
Displaces protein bound warfarin - increases bleeding risk
Antidepressant with potent enzyme autoinhibition Right Ans - Paroxetine
is a potent inhibitor of CYP2D6
Inhibits its own metabolism, dosing is is non-linear
Increasing dose by 50% causes 2x increased plasma concentration
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