Exam (elaborations)
SPMM Adult Psychiatry MCQs – Correctly Answered
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SPMM Adult Psychiatry MCQs – Correctly Answered
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SPMM Adult Psychiatry MCQs – Correctly AnsweredDepot that is comparatively good for symptom control but causes EPSEs
Right Ans - zuclopenthixol
effective as comparator depot typical antipsychotics in treating schizophrenia
and chronic psychosis but there is evidence to suggest it may induce more
EPSEs
Most effective intervention for weight reduction in schizophrenia Right
Ans - lifestyle counselling
exercise interventions
others;
psychoeducation
aripiprazole augmentation
topiramate
D-fenfluramine
metformin
Most effective intervention in waist circumference reduction in schizophrenia
Right Ans - aripiprazole augmentation
topiramate
others
dietary interventions
most effective intervention in reducing glucose levels in schizophrenia
Right Ans - switching from olanzapine to quetiapine or aripiprazole
metformin
others
glucagon-like peptide 1 receptor agonists
dietary interventions
aripiprazole augmentation
most effective intervention in improving insulin resistance in schizophrenia
Right Ans - metformin
rosiglitazone
,most effective intervention for triglycerides and LDLs in schizophrenia
Right Ans - topiramate
others;
lifestyle interventions
most effective intervention for total cholesterol and HDL in schizophrenia
Right Ans - metformin
others;
lifestyle interventions - for total cholesterol
NMS in depots and oral Right Ans - risk is equal
NMS is not a contraindication to subsequent depot use
medication with highest evidence of reducing suicidality in schizophrenia
Right Ans - clozapine - InterSePT trial showed 26% reduction compared to
olanzapine
Treatment of Body Dysmorphic Disorder Right Ans - * SSRI medication -
fluoxetine and escitalopram
* Exposure with Response Prevention
* Cognitive Therapy
* Cosmetic surgery doesn't work.
D-cycloserine Right Ans - glycine site partial agonist
shown to improve negative symptoms at daily dose of 50mg in patients
treated with first generation antipsychotics and at dose of 100mg/d in
medication free patients
dysregulation of N-methyl D-aspartate (NMDA) receptor signalling has been
implicated in schizophrenia - sustained increase in agonist activity at glycine
site of NMDA receptor has had benefit on negative symptoms of schizophrenia
effect of ketamine infusion in schizophrenia Right Ans - single infusion of
ketamine shown to produce social withdrawal, attenuated psychotic
, symptoms and memory impairment in healthy subjects and a transient
relapse of psychosis in schizophrenia
CATIE trial Right Ans - -Clinical Anti-psychotic Trials Intervention
Effectiveness
-200
-done by the national institutes of mental health over 4 years
-study: compared long term effectiveness of typical (perphenazine) vs atypical
anti-psychotic drugs (olanzapine, quetiapine, risperidone, ziprasidone)
-results: typical and atypical anti-psychotics are equally effective
BAP guidelines for pharmacological management of persistent
hostility/aggression in schizophrenia Right Ans - - clozapine best evidence
- olanzapine advantages over other antipsychotics
expressed emotion Right Ans - The general level of criticism, disapproval,
and hostility expressed in a family. People recovering from schizophrenia are
considered more likely to relapse if their families rate high in expressed
emotion. >35 hours a week with relative of high expressed emotion score
increased risk of relapse
orignally developed by Brown and Rutter in 1966 as part of Camberwell
Family Interview, later modified by Vaughn and Leff
5 measures;
1. critical comments
2. positive remarks
3. emotional overinvolvement
4. hostility
5. emotional warmth
psychosocial interventions with established evidence base in management of
schizophrenia Right Ans - CBT
family intervention
psychoeducation
vocational/employment interventions
obstetric complications as risk factors for schizophrenia Right Ans -
pregnancy complications;
- bleeding
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