1. Atorvastatin Calcium
Answer
- Lipitor
- Antihyperlipidemic (statin)
- Hyperlipidemia
- 10 to 80 mg qd
- Oral route any time of the day w or w/o food
- Contraindications
- Major interactions
atorvastatin; grapefruit juice
- Side effects;systemic vasculitis; alopecia; new onset diabetes mellitus; GI upset; acute
hepatitis; liver failure
- MOA; selectively and competitively inhibits HMG-CoA reductase, a rate-limiting enzyme
that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a sterol and cholesterol
precursor
2. Levothyroxine
Answer
- Synthroid
- Diagnostic agent
- Hypothyroidism
- mcg increments
- Injection, IV, or oral
- Contraindications; AMI; hypersensitivity to glycerol; unable to swallow capsules; risk of
thyrotoxicosis; adrenal insufficiency
- Major interactions; drugs that increase BP; soy in diet may decrease effectiveness of drug
,- Side effects; palpitations; alopecia; excessive sweating; weight loss; diarrhea; insomnia;
anxiety, fatigue; heart failure, MI; cardiac arrest; dyspnea; decreased bone density
- MOA; activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins
- Major Interactions
potassium; angiotensin enzyme inhibitors
- MOA
ACE inhibition prevents the conversion of angiotensin I to angiotensin II, which is a potent
vasoconstrictor. Decreased angiotensin II leads to decreased vasopressor activity and decreased
aldosterone secretion
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