Nurs 5220 test 1 Questions With 100% Correct Answers
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Nurs 5220
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Nurs 5220
Nurs 5220 test 1 Questions With 100% Correct Answers
.Are there any significant anesthetic interactions? - ANSWER-There are no known significant anesthetic interactions.
.Do transdermal selegiline require dietary restrictions? - ANSWER-No, transdermal selegiline does not require dietary restr...
Nurs 5220 test 1 Questions With 100%
Correct Answers
.Are there any significant anesthetic interactions? - ANSWER-There are no known significant anesthetic
interactions.
.Do transdermal selegiline require dietary restrictions? - ANSWER-No, transdermal selegiline does not
require dietary restrictions.
.Does levodopa have an effect on non-dopaminergic aspects of Parkinson's disease? - ANSWER-No
appreciable effect on non-dopaminergic aspects of disease (dementia & autonomic dysfunction)
.Does midazolam produce reliable retrograde amnesia? - ANSWER-No
.How are benzodiazepines metabolized? - ANSWER-They are oxidized in the liver via CYP enzymes,
primarily CYP3A4.
.How are dopamine agonists metabolized? - ANSWER-Primarily in the liver, with Pramipexole excreted
90% unchanged in urine and Apomorphine undergoing extensive first-pass inactivation and systemic
oxidation metabolism
.How do benzodiazepines work? - ANSWER-They promote the binding of GABA to the GABAA receptor,
enhancing GABA-induced chloride currents and inhibiting neuronal cell excitation.
.How do high dose glucocorticoids reduce the risk of needing post-op ventilatory support? - ANSWER-
Not specified
.How do hypnotic doses of benzodiazepines affect sleep-related breathing disorders? - ANSWER-Worsen
by adversely affecting control of upper airway muscles and decreasing ventilatory response to CO2
,.How do the discontinuation symptoms compare to amphetamine? - ANSWER-Discontinuation
symptoms are generally less pronounced than for amphetamine.
.How does the drug interact with sympathomimetic drugs? - ANSWER-It may unpredictably alter the
response to sympathomimetic drugs.
.How does the drug's arrhythmogenic potential compare to amphetamine and methylphenidate? -
ANSWER-It is generally less arrhythmogenic, but events have been described.
.How is amphetamine metabolized? - ANSWER-CYP 2D6 (no active metabolites)
.How is Carbamazepine metabolized? - ANSWER-Liver, active metabolite, strong CYP inducer
.How is Lamotrigine metabolized? - ANSWER-Hepatic and renal
.How is Levodopa transported into the CNS? - ANSWER-Actively transported
.How is methylphenidate metabolized? - ANSWER-Hepatic via carboxylesterase CED1A1 to inactive
metabolites, CYP 3A4
.How is Midazolam utilized in anesthesia? - ANSWER-As a short-acting benzodiazepine
.How is Phenytoin metabolized? - ANSWER-Liver, first-order kinetics at therapeutic doses, capacity
limited at higher doses
.How is Valproate metabolized? - ANSWER-Liver
.How long does the effect of midazolam usually last? - ANSWER-20-30 minutes
.How often are multiple doses of levodopa required daily? - ANSWER-Multiple doses are required daily
, .In which patients is prophylactic use of anticonvulsants recommended? - ANSWER-Patients with
tumors, brain injuries, and intracerebral hemorrhages
.Is withdrawal possible in a benzo-dependent patient? - ANSWER-Yes
.What anticonvulsant gained favor with similar efficacy to phenobarbital? - ANSWER-Phenytoin
.What anticonvulsant was historically widely used? - ANSWER-Phenobarbital
.What are benzodiazepines? - ANSWER-A class of drugs used for anxiety and other purposes.
.What are common side effects of most anticonvulsant agents? - ANSWER-Dizziness, somnolence,
headaches, and memory impairment
.What are some common adverse effects of psychostimulants? - ANSWER-Insomnia, headache, anxiety,
weight loss, tachycardia, HTN
.What are some common psychostimulants? - ANSWER-Amphetamine, Methylphenidate, Modafinil
.What are some examples of immune modulators? - ANSWER-Corticosteroids, cyclosporine,
azathioprine, tacrolimus, rituximab
.What are some serious adverse effects of psychostimulants? - ANSWER-Arrhythmias, seizure,
hyperpyrexia
.What are the active metabolites of benzodiazepines? - ANSWER-Diazepam (with a half-life exceeding
100 hours) and midazolam (rapidly metabolized to an α-hydroxylated compound with biologic activity).
.What are the adverse effects of AAAD inhibitors? - ANSWER-Nausea, somnolence, psychosis, cardiac
irritability, orthostatic hypotension
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