100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
WGU 785 FINAL EXAM QUESTIONS AND ANSWERS $12.99   Add to cart

Exam (elaborations)

WGU 785 FINAL EXAM QUESTIONS AND ANSWERS

 5 views  0 purchase
  • Course
  • WGU C785
  • Institution
  • WGU C785

WGU 785 FINAL EXAM QUESTIONS AND ANSWERS

Preview 3 out of 23  pages

  • October 16, 2024
  • 23
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • WGU C785
  • WGU C785
avatar-seller
GEEKA
WGU C785 BIOCHEMISTRY UNIT QUESTIONS
Which level of protein structure is disrupted through the hydrolysis of peptide bonds?

Quaternary

Tertiary

Primary

Secondary - Answers-Primary

The primary structure of a protein is the sequence of amino acids held together by
peptide bonds. Peptide bonds are formed by dehydration reactions and disrupted by
hydrolysis.

A mutation in the beta-hemoglobin gene, which results in the replacement of the amino
acid glutamate in position 6 with the amino acid valine, leads to the development of
sickle cell anemia. The structures of glutamate and valine are shown below.

If the beta hemoglobin gene in a patient with sickle-cell anemia were to be edited so
that the valine in position 6 was replaced with a different amino acid, which replacement
for valine would be expected to have the best clinical outcome, in theory, for the
patient? (Assume the valine can potentially be replaced with any amino acid other than
glutamate.) - Answers-The original amino acid in a healthy patient is glutamate, which is
negatively charged. The mutated amino acid is valine, which is non-polar. Valine is
causing sickle cell anemia. The best amino acid to replace valine so that the patient is
healthy again would be the one most like glutamate, so any negatively charged amino
acid.

Secondary, tertiary, and quaternary levels of protein structure can all be impacted by
exposing a protein to which treatment?

Change of a hydrophobic amino acid to a different hydrophobic amino acid

Addition of a reducing agent

Placement of the protein in a solution with a low pH

Increase in the concentration of the protein in solution - Answers-Placement of the
protein in a solution with a low pH

Changes in pH affect hydrogen bonds and ionic bonds. Hydrogen bonds in the
backbone of amino acids occur in secondary structure, and both hydrogen bonds and
ionic bonds occur in the side chains of amino acids in tertiary structure.

,An increase in beta-pleated sheet structure in some brain proteins can lead to an
increase in amyloid deposit formation, characteristic of some neurodegenerative
diseases. What is the primary biochemical process that follows the increase in beta-
pleated sheet structure that leads to the development of the amyloid deposits?

An increase in glycogen formation in the brain cells

Aggregation of the proteins in the brain

Secretion of glucagon, leading to excessive ketogenesis

An increase in anaerobic metabolism of glucose in the brain - Answers-Aggregation of
the proteins in the brain

This question is describing changes in protein structure. Aggregation occurs when
proteins clump together inappropriately, causing plaques like amyloid deposits to
accumulate.

Which level of protein structure is determined by the sequence of amino acids?

Secondary structure

Quaternary structure

Tertiary structure

Primary structure - Answers-Primary structure

The primary structure of a protein is simply the sequence of amino acids held together
by peptide bonds.

Which force is most influential in determining the secondary structure of a protein?

Hydrophobic effect

Disulfide bonding

Hydrogen bonding

Electrostatic interactions - Answers-Hydrogen bonding

The secondary structure of a protein is built by hydrogen bonds between the carboxyl
groups and amino groups on the backbones of the amino acids.

Which amino acid would most likely participate in hydrogen bonds? - Answers-Amino
Acid structure 4

, This is a polar, uncharged amino acid due to the OH group on the side chain. Polar,
uncharged amino acids containing oxygen or NH groups make hydrogen bonds.

Which portion of the amino acid is inside the box?

The box is surrounding the section below the Alpha Carbon - Answers-Side Chain

The side chain is the variable group of the amino acid, also called the R group. Every
amino acid has the same amino group, carboxylic acid group, and an alpha carbon, but
the side chain is different.

Which pair of amino acids will most likely interact through hydrophobic forces between
their side chains? - Answers-Both of these amino acids are non-polar and therefore can
interact together with a hydrophobic interaction. Please note that the "S" in the amino
acid on the right is non-polar, while the "SH" group in answer choice D is polar. The S
must have an H to be polar and is otherwise non-polar.

Which portion of the amino acid is inside the box?

The box is over the Carbon at the Center of the chain - Answers-Alpha Carbon

The alpha carbon is the central carbon on an amino acid that holds together the other
groups of the amino acid. It is always attached to the amino group, the carboxyl group,
the side chain, and a single hydrogen. It is part of the backbone of the amino acid and is
found in every amino acid.

Given the following amino acid structure, what is the strongest intermolecular force it
would participate in to stabilize a protein structure?

Ionic bond

Disulfide bond

Hydrogen bond

Hydrophobic interaction - Answers-Hydrophobic interaction

The amino acid pictured only has CH groups in its side chain, and therefore is non-
polar. Non-polar amino acids make hydrophobic interactions.

Which change would most likely result in a permanent modification of an expressed
protein's function?

An increase in the pH of a solution in which a protein is dissolved from 6.5 to 8.0, when
it is known that the protein has an optimal activity of pH 7.8

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller GEEKA. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $12.99. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

84866 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$12.99
  • (0)
  Add to cart