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NU 578 Unit 4 Study Guide with Complete Solutions

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NU 578 Unit 4 Study Guide with Complete Solutions Insulin use - Answer-Insulin is used to treat all patients with type 1 and many with type 2 diabetes. consists of two amino acid chains (a acidic and b basic) linked by two disulfide bridges. it is synthesized in the pancreas by b ce;;s within i...

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  • October 16, 2024
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EMILLECT 2024/2025 ACADEMIC YEAR ©2024 EMILLECT. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER, 2024




NU 578 Unit 4 Study Guide with
Complete Solutions

Insulin use - Answer✔✔-Insulin is used to treat all patients with type 1 and many with type 2

diabetes. consists of two amino acid chains (a acidic and b basic) linked by two disulfide bridges.

it is synthesized in the pancreas by b ce;;s within islets of langerhans. insulin is released by rise

in blood sugar (eating a. meal).




Anaolic reaction (insulin promotes conservation of energy and buildup of energy stores)


Insulin metabolic actions - Answer✔✔-Insulin promotes glucose into glycogen, amino acids

assembled into proteins, fatty acids into triglycerides.


Insulin deficiency promotes glycogen into glucose, proteins into amino acids, and fats into

glycerol.


Metformin use - Answer✔✔-Biguanide


used for type 2 DM. oral anti diabetic. may be used with other drugs. can be used for prevention

of type 2 diabetes, GDM, PCOS.




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,EMILLECT 2024/2025 ACADEMIC YEAR ©2024 EMILLECT. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER, 2024


Reduces GI absorbance of glucose and hepatic production of glucose. Does not stimulate insulin

release from the pancreas.




Increases HDL, decreases BP, promotes weight loss.


DPP-4 Inhibitors (gliptins) - Answer✔✔-go to pancreas and increase insulin release.


Example is Sitaglitpin


Sodium Glucose cotransporter 2 inhibitors (SGLT-2 inhibitors). (gliflozins) - Answer✔✔-Example:

empagliflozin


increases urine excretion of glucose, taken PO, reduces cardiovascular risk of type 2 diabetes.




SE: yeast infections and genital gangrene


Incretin Mimetics ('tides) - Answer✔✔-injectables that slow gastric emptying, causes weight

loss and help an overwhelmed pancreas.


solfonylureas - Answer✔✔-stimulate pancreas to release more insulin. range in onset, duration,

and potency and are only used for type 2 diabetes. there are first generation and second

generation. second are more potent and doses are lower and drug drug interactions are less

common




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AE: hypoglycemia


Acarbose - Answer✔✔-a glucosidase inhibitor




oral anti diabetic agent that inhibits breakdown of oligosaccharides into monosaccharides. this

delays digestion and prolongs absorption of carbs and decreases postprandial hyperglycemia!!




ADR: FI upset and flatulence.


take this with first bite of each meal.


Insulin Complications/ Drug Interactions - Answer✔✔-hypoglycemia caused by overdose.




hypoglycemic agents (sulfonylureas, glinides, and alcohol), hyperglycemia agents, b adrenergic

blocking agents.


Sitagliptin - Answer✔✔-DP4 inhibitor.


stimulates glucose dependent release of insulin and suppresses postprandial release of

glycogen. both actions help keep BG from climbing to ohhight. used for type 2 dm




AE: URI, headache, inflammation of nasal passages, pancreatitis, hypersensitivity reactions.


Canagliflozin - Answer✔✔-SGC2 inhibitor

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