Exam 2 blood bank transfusion and HDFN Questions 100% Solved.
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Course
Blood bank
Institution
Blood Bank
Exam 2 blood bank transfusion and HDFN
Questions 100% Solved.
HDN - answerDestruction of the fetus/ neonates RBCs by Abs produced by the mother. the
father passes on antigens to the baby that are different than the mothers
The mother can be stimulated to form the antibodies by previous pregnanc...
- how often does transplacental hemorrhaging of fetal RBCs into the maternal circulation occur?
- answer✔transplacental hemorrhage of fetal RBCs into the maternal circulation occurs in up to
7% of women during gestation. At delivery, the risk increased to about 50%
what else can be the cause hemorrhage - answer✔Test procedures (amniocentesis and chronic
villus sampling) and trauma can also be the cause of hemorrhage.
how many fetal RBCs are needed to stimulate the mother - answer✔only about 1 mL
Host factors that affect immunization - answer✔the ability of an individual to produce antibodies
in response to antigen exposure varies. some people will never produce an Ab even after repeat
exposure, where others will produce Abs to everything they are exposed to
Immunoglobulin class factors that affect immunization - answer✔IgG only class that can cross
the placenta
- IgG1 and IgG3 are more efficient in RBC hemolysis than IgG2 and 4
- types of subclasses the mother produces can affect the severity of the hemolysis
hemolysis - answer✔hemolysis occurs when the maternal AB attaches to the fetal RBC
- the AB coated RBCs are then removed from the circulation by the macrophages of the spleen
Rate of destruction depends on what - answer✔rate of destruction depends on titer and
specificity of the antibody and on the number of antigenic sites present on the RBCs
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