How much volume will the intravascular space increase with 1 liter of 5% albumin?
A. 1 liter
B. 500 mls
C. 250 mls
D. 100 mls ✔✔Answer: A. 1 liter - Remember that albumin is a large protein that cannot
escape the intravascular space - water will flow in to try to dilute the albumin out. More
concentrated albumin, the more fluid will flow into the intravascular space.
A patient presents with muscle rigidity, fever, and delirium. Labwork reveals normal LFT's,
normal renal panel, elevations in creatinine phosphokinase. Current medications include
lisinopril, aspirin, citalopram, valproic acid, risperidone, tramadol, and baclofen. Which agent
is the likely cause?
,A. Citalopram
B. Risperidone
C. Valproic acid
D. Baclofen ✔✔Answer: B. Risperidone - This is likely a case of NMS and antipsychotics have
a much higher incidence of causing this versus other medications.
A 68 year old male has a medical history of atrial fibrillation, essential tremor, diabetes, and
CHF. Over the past year, he has had worsening respiratory symptoms and
albuterol/ipratropium as needed and fluticasone/salmeterol has been added. Other
medications include warfarin, amiodarone, primidone, metformin, and aspirin. Which
medication is most likely to cause the respiratory symptoms?
A. Warfarin
B. Amiodarone
C. Primidone
D. Metformin ✔✔Answer: B. Amiodarone has the potential to cause pulmonary fibrosis.
What is the most likely agent that would cause the worsening confusion?
A. Propranolol
B. Insulin glargine
C. Naproxen
D. Ranitidine ✔✔Answer: D. Ranitidine - While propranolol can certainly cause some
cognition/sedation issues, the likely cause here with the change in kidney function is the
accumulation of ranitidine. H2 blockers are primarily eliminated via the kidney. Propranolol
is primarily eliminated via the liver.
, Which medications are most likely to cause an elevation in lithium levels?
A. Hydrochlorothiazide and Clozapine
B. Ibuprofen and Hydrochlorothiazide
C. Venlafaxine and Clozapine
D. Ibuprofen and Clozapine ✔✔Answer: B. Ibuprofen and Hydrochlorothiazide - NSAIDs and
thiazide diuretics are two classic examples of very common medications that can
potentially increase lithium concentrations. Whenever these medications are added or
increased, at a minimum ramped up monitoring is recommended.
In the case above, what is the target concentration for digoxin?
A. <0.5
B. 0.5-0.8
C. 0.8-1.2
D. 1.2-1.5 ✔✔Answer: B. 0.5-0.8 - Goal for CHF is 0.5-0.8.
A 55 year old male has a history of seizure disorder, GERD, muscle spasms, and bipolar
depression. Current plan is to add lamotrigine to current medication regimen. Current
medications include: Phenytoin, Valproic acid, omeprazole, and cyclobenzaprine.
Which medication is most likely to cause a significant increase in lamotrigine level?
A. Phenytoin
B. Valproic acid
C. Omeprazole
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