ASCP CGMBS Exam Study Questions and Answers 2024/2025
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Course
ASCP CGMBS
Institution
ASCP CGMBS
BCR;ABL1 fusion protein
→ t(9;22)(q34;q11)
Acute Promyelocytic Leukemia (APL)
→ t(15;17) a fusion of PML and RARA
Burkitt's Lymphoma
→ t(8;14) the breakpoints on chr.8 are spread of 190 kbp region 5' to and within the CMY C gene
Follicular Cell Lymphoma (FCL)
→ t(14;18) translocatio...
ASCP CGMBS Exam Study Questions and
Answers 2024/2025
BCR;ABL1 fusion protein
→ t(9;22)(q34;q11)
Acute Promyelocytic Leukemia (APL)
→ t(15;17) a fusion of PML and RARA
Burkitt's Lymphoma
→ t(8;14) the breakpoints on chr.8 are spread of 190 kbp region 5' to and within the C-
MY C gene
Follicular Cell Lymphoma (FCL)
→ t(14;18) translocation disregulate BCL2, which inhibits apoptosis in B lymphocytes,
which leads to survival of genetically damaged cells
Mantle Cell (MCL)
→ t(11;14) translocation increases expression of CCND1
Chronic Myelogenous Leukemia (CML)
→ t(9;22) aka Philadelphia Chromosome, translocation occurs within two genes: the
breakpoint cluster region (BCR) on chr.22 and the cellular counter part of the Abelson
Leukemia virus tyrosine kinase (c-abl) on chr.9
→ second-line drug for cutaneous T-cell lymphoma. Treatments are often used in
combination with phototherapy and chemotherapy
Irinotecan
→ UGT1A1 - Prevents DNA from unwinding by inhibition of topoisomerase 1
Warfarin (Coumadin)
→ CYP2C9 and VKORC1 - Vitamin K antagonist; metabolized primarily via oxidation in
the liver by CYP2C9 and exerts its anticoagulant effect by inhibiting the protein
vitamin epoxide reductase complex, subunit 1 (VKORC1)
Tamoxifen
→ CYP2D6 - anti estrogen therapy for hormone receptor-positive breast cancer in pre-
menopausal women
Azathioprine
→ TPMT - immunosuppresive used in organ transplant
Carbamazepine
→ Ineffective to HLA B1502
Plavix
→ CYP2C19 - anticoagulant (stroke, heart attack)
Herceptin
→ HER2/Neu - anti Her2/neu
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