NBME CBSE: Biochemistry (Molecular) ACTUAL TEST
QUESTIONS AND ANSWERS 2024/2025(Quiz bank with all
the correct answers)(usmle step 1)Medical examination
T/F Unmethylated CG patterns stimulate immune responses in the body.
True
What two bases are methylated by bacteria to protect them from viruses?
1) cytosine
2) adenine
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Histones contain basic aminor acids. What two positively charged AA's are high in content in histones?
1) lysine
2) arginine
A patient gets a fever with joint pain and a rash after being prescribed isoniazid from a doctor. What is a
probable prognosis?
Drug-Induced Lupus (anti-histone antibodies)
,What is the difference between drug induced and classic lupus?
1) drug-induced lupus is caused by anti-histone antibodies
2) classic lupus is caused by anti-dsDNA antibodies
What three classic drugs cause drug-induced lupus?
1) Hydralazine
2) Procainamide
3) Isoniazid
T/F Acetylated chromatin is ready for transcription?
True (deacetylation closes chromatin)
T/F Heterochromatin is transcribed more than Euchromatin.
False: Euchromatin is less condensed (acetylated)
T/F DNA methylation decreases transcription.
True
Huntingtons disease is a gain of function mutation that is classified as a movement disorder and leads to
neuronal cell death in striatum. What is a possible mechanism to suppress the gene?
, histone deacetylation
T/F Folate contributes to formation of pyrimidines.
What is an antiviral drug that inhibits IMP DH and blocks the conversion of IMP to GMP in purine
synthesis?
Ribavirin
What is an immunosuppressant drug that inhibits IMP DH and blocks the conversion of IMP to GMP in
purine synthesis?
mycophenolate
What is a chemotherapy agent that mimics hypoxanthine/guanine and is added to PRPP by HGPRT and
inhibits multiple steps in de novo synthesis of IMP, AMP, and GMP?
6-Mercaptopurine
What is an immunosuppressant drug that is converted to 6-mercaptopurine and functions in a similar
way?
Azathioprine
In Severe combined immunodefficiency syndrome (SCID) what enzyme is inhibited?
Adenosine Deaminase
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