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OST 575 - Hepatobiliary disorders I Exam 3
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OST 575 - Hepatobiliary disorders I Exam 3What is the process of cirrhosis? - ANSWER inflammatory cells damage parenchyma-->
parenchyma begins to collapse-->
new collagen laid down, leads to scarring-->
scar will bridge portal regions and central vein regions *leading to fibrosis/cirrhosis*
What is the gross anatomy of someone with liver cirrhosis? - ANSWER liver is smaller in
weight
distinct nodules are usually present
texture is very firm
yellow-green discoloration
What cells in the liver start the cascade of release of various cytokines to cause
damage? - ANSWER Kupffer cells
What cells become activated in response to hepatic injury and inflammation, leading to
their phenotypic changes allowing for collagen production and production of inhibitors
of matrix metalloproteinases to fill space of Disse? - ANSWER Stellate cells
What are the patterns of hepatic injury? - ANSWER Triaditis
Hepatitis
Cholangitis (cholestatic pattern)
Necrosis
What is Triaditis? - ANSWER Inflammation filling and expanding the portal triad region
, Triaditis that spills over into adjacent periportal hepatocytes and causes injury to them
is called what? - ANSWER Interface hepatitis
Inflammation filling and expanding the portal triad region is what type of hepatic injury? -
ANSWER Triaditis
What is Hepatitis? - ANSWER inflammation that surrounds and induces necrosis or
apoptosis in *hepatocytes*
Sometimes described as lobular inflammation
What is the formation of the lobular model of the liver? - ANSWER central vein at center
Hepatocytes throughout lobule
multiple portal tracts around lobular periphery
Inflammation that surrounds and induces necrosis or apoptosis in *hepatocytes* is what
type of hepatic injury? - ANSWER Hepatitis
What is Cholangitis? - ANSWER inflammation in and around *bile ducts*
Can be caused by cholestasis or large accumulations of bile
Inflammation in and around the *bile ducts* that can be caused by cholestasis or large
accumulations of bile is what type of hepatic injury? - ANSWER Cholangitis
What is necrosis of liver? - ANSWER hepatocyte cell death in a large obvious manner
due to injury capable of killing hepatocytes
What is often the first visible pattern of injury in the liver? - ANSWER Steatosis
What is steatosis? - ANSWER collection of lipid material inside the hepatocytes
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