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OST 575 Drugs Exam 2 Questions And Answers
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OST 575 Drugs Exam 2 Questions And Answers...
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OST 575 Drugs Exam 2 Questions And AnswersMetoclopramide MOA - ANSWER Dopamine receptor antagonist
-Increases LES tone
-Increases GI peristalsis
Metoclopramide adverse effects - ANSWER -Nervousness
-Drowsiness
-Dystonic reactions
-Breast tenderness and galactorrhea
Metoclopramide clinical uses - ANSWER -Antiemetic for pt's undergoing chemo
-GERD
-Esophagitis
Loperamide - ANSWER -Opiate-like MOA
-May cause constipation and toxic megacolon
-Used for acute nonspecific diarrhea and chronic diarrhea w/ IBD
Diphenoxylate and Atropine (Lomotil) - ANSWER -Antidiarrheal
-Atropine decreases likelihood of abuse
-Avoid if diarrhea is caused by toxic substances
Dicyclomine - ANSWER Anticholinergic that decreases GI motility and spasm
Drugs that may cause diarrhea - ANSWER -Antimicrobials (tetracyclines)
, -Cholinergic agonists
-Laxatives
-Metoclopramide
Laxative vs Catartics - ANSWER *Cathartic* - prompt, fluid evacuation
*Laxative* - soft, formed stool over longer period of time
Classification of laxatives - ANSWER 1. Luminally active
2. Nonspecific stimulants
3. Prokinetics
Psyllium - ANSWER -Laxative
-Luminally active
-Hydorphillic colloid
Docusate - ANSWER -Laxative
-Luminally active
-Surfactant and emollient
Prolonged use of stimulant laxatives may cause - ANSWER IBS
Stimulants frequently cause - ANSWER Intestinal cramping
Lubiprostone - ANSWER Prostanoic acid derivative
stimulates chloride secretion into GI increasing fluid content
USES: Laxative
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