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CHT Exam practice test Questions and Answers
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CHT Exam practice test Questions and Answers
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CHT Exam practice test Questions and AnswersPeptides that bind to MHC class I molecules differ from peptides that bind to MHC class II
molecules in all except which of the following ways?
a. They are shorter
b. They were processed by different proteases
c. They anchor in the middle instead of the end of the MHC molecule
d. They interact with different subsets of T cells Correct Ans-c. They anchor in the middle
instead of the end of the MHC molecule
HLA-DM is primarily involved in the
a. Activation of cytotoxic T cells
b. Loading antigen onto HLA-DR molecules
c. Preventing HLA-A molecules from folding prior to antigen binding
d. Rejection of islet grafts
e. Induction of diabetes mellitus Correct Ans-b. Loading antigen onto HLA-DR molecules
The antigen-binding site of an antibody is comprised of which of the following?
a. The variable region of the light and heavy chains
b. The variable region of the light chain only
, CHT Exam practice test Questions and Answers
c. The entire light chain
d. The entire heavy chain
e. The Fc portion of the immunoglobulin molecule Correct Ans-a. The variable region of
the light and heavy chains
The immunoglobulin that binds the most complement is
a. IgA
b. IgD
c. IgM
d. IgG2
e. IgE Correct Ans-c. IgM
The immunoglobulin responsible for activating mast cells in an allergic response is
a. IgA
b. IgD
c. IgM
d. IgG
e. IgE Correct Ans-e. IgE
, CHT Exam practice test Questions and Answers
The molecular interaction between an antibody and its corresponding antigen is mediated by
all except which of the following?
a. Hydrogen bonds
b. Hydrophobic interactions
c. Covalent bonds
d. Electrostatic interactions
e. Van der Waals interactions. Correct Ans-c. Covalent bonds
The phenomenon of 'affinity maturation,' in which later antibodies bind to antigen with a
higher affinity than the ones made weeks earlier, is due to
a. Allelic exclusion
b. VDJ recombination
c. Isotype switching
d. Junctional flexibility
e. Somatic hypermutation Correct Ans-e. Somatic hypermutation
Positive and negative selection of T cells occurs...
a. Before TCR gene rearrangement
b. After TCR gene rearrangement
, CHT Exam practice test Questions and Answers
c. After T cells have left the thymus
d. In the bone marrow
e. In the spleen Correct Ans-b. After TCR gene rearrangement
Antibodies in the serum of a transplant recipient that react with HLA class I (HLA-A,B,C)
antigens on the donor are particular dangerous in that they can induce...
a. Hyperacute rejection
b. Acute rejection
c. Chronic rejection
d. Type III hypersensitivity reactions
e. Type I anaphylactic reactions Correct Ans-a. Hyperacute rejection
Which of the following immunosuppressive drugs could be classified as an antiproliferative
(anti-metabolite)?
a. Cyclosporine
b. FK506
c. Rapamycin
d. Azathioprine
e. Prednisolone (steroids) Correct Ans-d. Azathioprine
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