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RUSH NSG 531: ADVANCED PHARMACOLOGY EXAM 2
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RUSH NSG 531: ADVANCED PHARMACOLOGY EXAM 2
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RUSH NSG 531: ADVANCED PHARMACOLOGY EXAM 2Potency - Answers-Dose of drug required to produce given effect; 50% of maximal
response the drug is capable of producing
Efficiacy - Answers-Maximal response a drug is capable of producing
Ka - Answers-Volume needed to get one mole of an unbound drug when 50% of target
receptors are occupied. L/mole
Kd - Answers-Concentration of drug in the plasma when 50% of the target receptors are
occupied. Mole/L
Non-competitive (irreversible) antagonist LDR curve - Answers-Moves to the right and
down
Competitive (reversible) antagonist LDR curve - Answers-Moves to the right and parallel
Clonidine - Answers-Alpha 2 receptor prototypic agonist
Antihypertensive: inhibits NE release by binding to presynaptic alpha 2 receptors,
inhibits sympathetic outflow in CNS (these are greater than vasoconstrictive effects)
Beta 1 receptors - Answers-Heart: increase cardiac rate (chronotropic) and increase
force of contraction (inotropic)
Juxtaglomerular cells: increase renin release
Isoproterenol - Answers-Beta 1 prototypic agonist; nonselective, used for
bronchodilation (beta 2) and cardiac stimulant (beta 1)
Metoprolol - Answers-Beta 1 prototypic antagonist
Heart: reduces rate and force of contraction, inhibits impulse conduction
Kidney: suppresses renin secretion
Beta 2 receptors - Answers-Lungs: bronchodilation
Skeletal muscles: vasodilation
Albuterol - Answers-Beta 2 prototypic agonist; used to manage asthma
Rocuronium - Answers-Nondepolarizing neuromuscular blocker; reversed used
neostigmine
Succinylcholine - Answers-Depolarizing neuromuscular blocker; has short half-life so
can wait for natural reversal
Glutamate - Answers-Excitatory neurotransmitter
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