ERAD pathway - ✔✔- oligosaccharide chain is removed and protein is
poly-ubiquinated
- UB-protein binds to cap of proteasome, the UB is removed and recycled
and the protein is threaded into the proteasome and degraded
- AAs are reused for new protein synthesis
mono-UB - ✔✔serves as signal for membrane protein import into late
endosomal intralumenal vesicles
poly-UB - ✔✔serves as signal for ER protein degradation and for most
other cellular proteins destined for normal turnover
calnexin - ✔✔membrane-bound reticuloplasmin
UGGT monitoring enzyme - ✔✔glycosyltransferase that recognizes
hydrophobic residues that are usually masked by the attached
oligosaccharide core in a correctly folded protein
UPR pathway - ✔✔unfolded protein response
occurs under ER stress (misfolded proteins accumulate in ER to high levels
due to overload of ERAD pathway)
two types: PERK and ATF-6
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