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NR566 MIDTERM QUESTIONS AND ANSWERS
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NR566 MIDTERM QUESTIONS AND ANSWERS
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NR566 MIDTERM QUESTIONS AND ANSWERSPenicillin - prescribing in pregnant patients - Answers-no second or third trimester fetal
risk
Penicillin cross sensitivity - Answers-Cephalosporins, carbapenems
Cephalosporins - patient education - Answers-Alcohol - induces a state of alcohol
intolerance
Drugs that promote bleeding - caution if drugs are combined with other agents that
promote bleeding (anticoagulants, thrombolytics, NSAIDs, antiplatelets)
Cephalosporins - prescribing in pregnant patients - Answers-safe for pregnant patients
Tetracycline - drug interactions - Answers-do not take with calcium and iron
supplements
it can also increase digoxin levels
Tetracycline - side effects - Answers-Discoloration of teeth --avoid in children < 8 years
old
Sun exposure risk - sunscreen, protection, avoid sunbed
Tetracycline - prescribing in pregnant patients - Answers-Causes fetal harm in pregnant
-- can suppress growth of long bones in premature infants
Macrolides - patient education - Answers-Administer with meals - GI effects
Macrolides - black box warning - Answers-QT prolongation and sudden cardiac death
Avoid in patients taking CYP3A4 inhibitors like CCB (Verapamil and diltiazem), azole
antifungal drugs, HIV protease inhibitors, and nefazodone (antidepressants)
Macrolides - drug interactions - Answers-inhibition of CYP450 -> elevated levels of
-theophylline
-carbamazepine
-warfarin
(Risk for toxicity)
Aminoglycosides - neurotoxicity/ototoxicity - Answers-Irreversible ototoxicity
-withdrawal med at first sign of damage: tinnitus, persistent headache (or both)
-Neurotoxic symptoms: numbness, tingling, muscle twitching, seizures.
Aminoglycoside- nephrotoxicity - Answers-increased risk with high doses, prolonged
use, and in patients with preexisting impairment
, Aminoglycoside - neuromuscular blockade - Answers-Can inhibit neuromuscular
transmission causing flaccid paralysis and potentially fatal respiratory depression
most episodes have occurred after intraperitoneal or intrapleural instillation of
aminoglycosides.
Sulfonamides - patient education - Answers-●Drink a minimum of 8-10 glasses of H2O
qd
(minimizes crystallization of sulfonamides).
●Avoid prolonged sun exposure
Sulfonamides - prescribing in pregnant women - Answers-can cause birth defects --
especially if in the first trimester
if taken near term -> kernicterus
treatment of tinea capitis - Answers-oral griseofulvin or terbinafine
Drug to treat aspergillosis - Answers-Voriconazole (Vfend)
Anthelmintic drug that carries risk for HYPOTENSION with patients on
antihypertensives - Answers-Ivermectin
Moxidectin
Anthelmintic drug that carries risk for BONE MARROW SUPPRESSION and LIVER
IMPAIRMENT - Answers-Mebendazole
Albendazole
Anthelmintic drug that is safe WITHOUT baseline data - Answers-Pyrantel Pamoate
Anthelmintic drug that is SAFE FOR PREGNANCY - Answers-Praziquantel
Moxidectin
Risks with didanosine (HIV medication) - Answers-Lactic acidosis
Severe hepatomegaly with steatosis
Risks with saquinavir (HIV medication) - Answers-Dangerous drug interaction with
ritonavir
PR prolongation
QT prolongation
Diabetes
PR interval prolonging HIV medication - Answers-Atazanavir
Lopinavir with ritonavir
Saquinavir
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