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AOCNP Test Review 2024/2025 Actual Exam Questions and Answers 100% Solved

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AOCNP Test Review 2024/2025 Actual Exam Questions and Answers 100% Solved Treatments that place individuals at increased risk for infection - Chemotherapy treatments including high-dose cyclophosphamide, doxorubicin, docetaxel, or alemtuzumab. Colony stimulating factors (CSF) - **GM-CSF : gro...

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  • October 10, 2024
  • 95
  • 2024/2025
  • Exam (elaborations)
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  • AOCNP
  • AOCNP
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JOSHCLAY
©JOSHCLAY 2024/2025. YEAR PUBLISHED, 2024.
AOCNP Test Review 2024/2025 Actual

Exam Questions and Answers 100%

Solved


Treatments that place individuals at increased risk for infection -

✔✔Chemotherapy treatments including high-dose cyclophosphamide,

doxorubicin, docetaxel, or alemtuzumab.

Colony stimulating factors (CSF) - ✔✔**GM-CSF : growth factor for

hematopoietic stem cells and granulocyte/monocytes

**M-CSF (macrophage): essential for macrophage production

**G-CSF (granulocyte) :essential for neutrophils

**Erythropoietin (EPO): growth factor for RBC

Filgrastim (Neupogen)

Pegfilgrastim (Neulasta)

Tbo-filgrastim (Granix) - ✔✔Common side effects: mild to moderate

bone pain

Used to patients at risk of experiencing treatment induced neutropenia

,©JOSHCLAY 2024/2025. YEAR PUBLISHED, 2024.
Major benefit: reducing the possibility of myelosuppression and permitting

the continuation of therapeutic chemotherapy doses

Filgrastim (Neupogen) - ✔✔Dose: 5 µg per kilogram per day. Begin 24 to

72 hours after completion of chemotherapy and continue through the post

nadir period.

Pegfilgrastim (Neulasta) - ✔✔That was: 6 mg per cycle. Again 1 to 3

days post chemotherapy. Administer as a single 6 mg injection once per

cycle. Do not administer in the period beginning 14 days before until 24

hours after administration of chemotherapy.

Antimicrobial prophylaxis for infection - ✔✔Low risk: no prophylaxis

Recommended unless the patient has prior herpes simplex virus episode.



Intermediate risk:

Bacterial: consider Fluoroquinolone

Fungal: consider fluconazole during neutropenia and if mucositis is

anticipated

Viral: during neutropenia and at least 30 days after transplantation



High risk:

Bacterial: consider fluoroquinolone

,©JOSHCLAY 2024/2025. YEAR PUBLISHED, 2024.
Fungal: consider fluconazole or other anti-fungal agent

Viral: during neutropenia and at least 30 days after transplantation

Graft versus host disease: penicillin andtrimethroprim/sulfamethoxazole

(tmp/smx) Or equivalent for allogenic heamatopoetic Stem cell transplant

recipients

Alemtuzumab: TMP/SMX

Complete diagnostic work up for neutropenic fever - ✔✔Blood cultures:

bacterial, viral, and fungal

BUN, electrolytes, and creatinine

Chest x-ray

CBC and differential

Liver function test

Pulse oximetry

Site-specific cytology and cultures

Urinanalysis

ANC calculation - ✔✔WBC x [(% segs + % bands)/100]

aplastic anemia - ✔✔a normocytic-normochromic type of anemia

characterized by the failure of bone marrow to produce red blood cells

, ©JOSHCLAY 2024/2025. YEAR PUBLISHED, 2024.
hemolytic anemia - ✔✔characterized by an inadequate number of

circulating red blood cells due to the premature destruction of red blood

cells by the spleen

deficiency anemia - ✔✔anemia caused by lack of necessary nutrients

B12, folate, and iron

Anemia # of RBC/ MCV - ✔✔Microcytic. Normocytic. Macrocyctic.

Microcytic anemia with ↓ serum iron, ↓ total iron-binding capacity (TIBC),

and normal or ↑ ferritin. - ✔✔cells smaller than normal

Iron deficiency

macrocytic anemia - ✔✔due to folate or vitamin B12(cobalamin)

deficiency (megaloblastic anemia), THF-M --> VitB12-M --> Methionine,

(transfer of methyl groups)

erythrpoietin (EPO) - ✔✔Stimulates development of RBC production

Triggered to release by reduced oxygen level of RBC mass trigger from the

kidney

Labs to check in anemia - ✔✔CBC with diff

Peripheral smear

Reticulocyte count

Iron studies: serum iron, total iron binding capacity, ferritin

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