ACETYLCHOLINE
Transmitter released by all preganglionic neurons of the sympathetic nervous system, all
preganglionic neurons of the parasympathetic nervous system, all postganglionic neurons of the
parasympathetic nervous system, postganglionic neurons of the sympathetic nervous system
that go to sweat glands, and all motor neurons.
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ACTIVATION OF ALPHA 1 RECEPTORS
Contracts the radial muscle of the eye (causing mydriasis), constricts veins and arterioles,
promotes ejaculation, and contracts smooth muscle in the prostatic capsule and bladder (trigone
and sphincter).
ACTIVATION OF BETA 1 RECEPTORS
Increases heart rate, force of myocardial contraction, and conduction velocity through the
atrioventricular node and promotes release of renin by the kidney.
ACTIVATION OF BETA 2 RECEPTOS
, Dilates the bronchi, relaxes uterine smooth muscle, increases glycogenolysis, enhances
contraction of skeletal muscle, and dilates arterioles (in the heart, lungs, and skeletal muscle).
EPINEPHRINE
Major transmitter released by the adrenal medulla.
Activates alpha1, alpha2, beta1, and beta2 receptors.
NOREPINEPHRINE
Transmitter released by all postganglionic neurons of the sympathetic nervous system, except
those that go to sweat glands.
PNS TRANSMITTERS
Acetylcholine, norepinephrine, and epinephrine
ACTIVATION OF DOPAMINE RECEPTORS
Dilates blood vessels in the kidney
What does the nurse need to know to learn and understand peripheral nervous system drugs?
Select all that apply.
The nurse must make a decision to determine if the receptor activation is a positive or negative
result for the patient
Whether the drug increases or decreases receptor activation
The normal responses to activation of those receptor
Neurotransmitter life cycle
The nurse must make a decision to determine if the receptor activation is a positive or negative
result for the patient.
Whether the drug increases or decreases receptor activation
The normal responses to activation of those receptor
The identity of the receptors at which that drug acts.
ACTIVITY 2
NSG124.13.01.02 MUSCARINIC AGONISTS
Bethanechol [Urecholine] embodies the properties that typify all muscarinic agonists. The nurse
knows which of the following are true regarding this drug? Select all that apply.
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