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NU 643 FINAL EXAM STUDY GUIDE LATEST AND UPDATED REGIS COLLEGE. $16.49   Add to cart

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NU 643 FINAL EXAM STUDY GUIDE LATEST AND UPDATED REGIS COLLEGE.

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NU 643 FINAL EXAM STUDY GUIDE LATEST AND UPDATED REGIS COLLEGE.

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  • October 8, 2024
  • 21
  • 2024/2025
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  • NU 643
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NU 643 FINAL EXAM STUDY GUIDE
LATEST AND UPDATED REGIS COLLEGE.
Inverse agonist binding
✔✔cause inactivation of signal transduction


A neurotransmitter binds to a receptor
✔✔causing electrical impulses to travel the neuron's axon; it eventually
releases the neurotransmitter and repeats the process with a postsynaptic
neuron, classical synaptic neurotransmission


True of pharmacokinetics
✔✔Accumulation of psychotropic drugs occurs faster in the brain than
adipose tissue


CYP450 TABLE
✔✔inhibitors and substrates INCREASE effectiveness of drug metabolized
inducers DECREASE effectiveness


Two main targets of signal transduction
✔✔gene expression and phosphoproteins


antagonist binding to receptor
✔✔unchanged signal transduction


first pass effect
✔✔metabolism of the drug in the liver, prior to reaching systemic
circulation

,Partial agonist binding to receptor
✔✔signal transduction is partially enhanced


Phase 1 metabolism
✔✔CYP450 enzyme activity


Phase 2 metabolism
✔✔conjugation of drug


G-linked proteins
✔✔bind enzymes that synthesize second messenger


Enzyme inhibition as a target of drug therapies
✔✔a means of preventing the degradation of neurotransmitters


ligand-gated ion channel
✔✔Allosteric modulators can enhance or inhibit ion channels when in the
presence of neurotransmitter


agonist binding to receptor
✔✔singal transduction is fully enhanced antagonist, in the presence of an
agonist, can return a channel to resting state


retrograde neurotransmission
✔✔the flow of neurotransmitter from postsynaptic neuron to presynaptic
neuron

, pharmacodynamics
✔✔action of drugs on body


pharmacokinetics
✔✔action of body on drugs


concentration-time curve of medication absorption
✔✔Steady-state refers to the point at which blood level fluctuations are
mild and not clinically significant.


volume neurotransmission
✔✔the diffusion of neurotransmitter to nearby neurons


second messengers
✔✔intracellular messengers activated by extracellular messengers


The direct role of transcription factors is to
✔✔influence gene expression


buproprion
✔✔wellbutrin....SNRI....may have affect for ADHD


comparing desvenlafaxine to venlafaxine
✔✔Desvenlafaxine likely no more efficacious venlafaxine

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