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Breast Pathoma: Questions With Complete Solutions
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Breast Pathoma: Questions With Complete Solutions
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Breast Pathoma: Questions With Complete SolutionsMilk line Right Ans - Breast tissue can develop anywhere from the axilla to
the vulva
Lobules and ducts are lined by two layers of epithelium Right Ans - luminal
cells - milk production
myoepithelial cells - contractile function
Is galactorrhea a symptom of Breast cancer? Right Ans - No
caused by nipple stimulation, prolactinoma and dopamine anatagonists
Acute mastitis in breast feeding women is usually caused by ________
Tx? Right Ans - *Staph aureus* invasion of fissures that develop during
*breast feeding*
Tx: *dicloxacillin*
70%-80% of cancers that are detected on mammogram are ______ Right Ans
- invasive
Risk factors for breast cancer? Right Ans - -benign breast disease
-estrogen exposure
-radiation (hodgkins tx)
-Obesity & alcohol
Poorly differentiated medullary cancers, ER- HER2- basal genetic
classification.
, genetic marker? Right Ans - BRCA1
more Poorly differentiated, more likely ER+, HER-
Luminal genetic classification
What gene? Right Ans - BRCA2
Chromosome 1q, overexpression of homeobox transcription factor HOXB13
Right Ans - Phyllodes tumor
Malignant clonal proliferation limited to ducts and lobules (has not broken
through the basement membrane)
• Stage 0 breast cancer
• Myoepithelial cells preserved Right Ans - DCIS
Atypical apocrine adenosis thought to be precursor, amplification of TP53 on
chrom 17q, ER + or ER- Right Ans - HER2 positive pathway
Most common mutation in sporadic cancer Right Ans - TP53
Which three are the most likely fibrocystic changes to cause cancer? Right
Ans - Atypical ductal > lobular
Atypical ductal and lobular hyperplasias have what change in genetic
material? Right Ans - loss of 16q or gain of 17p
Atypical lobular hyperplasia has a loss of E-cadherin
erythematous breast w/ purulent nipple discharge Right Ans - acute
mastitis
Smoker with subareolar mass and nipple retraction.
Location? Right Ans - periductal mastitis
Squamous metaplasia of lactiferous ducts
Periareolar mass w/ green-brown (or *thick white*) nipple discharge.
age group? disease? MOA? Right Ans - -Mammary Duct Ectasia
-Multiparous postmenopausal women
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